Maratuaba
MARATUABA is a popular combination of two well-known plants from the Brazilian Pharmacopoeia—Marapuama and Catuaba—which support the cardiovascular system by promoting vasodilation (widening of blood vessels) and helping maintain their elasticity. It is used when blood pressure is elevated and for the prevention of serious conditions such as coronary heart disease, its acute form—myocardial infarction—and stroke.
Muira puama acts as an effective neuroprotective agent: it helps protect brain cells (neurons) from damage and supports the quality of nerve impulse transmission. It is also considered one of the few natural remedies that can activate the so-called nerve growth factor in the central and peripheral nervous systems. Muira puama is often used to support cognitive function and to help prevent dementia, including in Alzheimer’s and Parkinson’s disease.
Muira puama is also known as a mild central nervous system stimulant and is used in cases of increased anxiety, low mood, stress, and sleep disturbances.
These two trees are also used together to boost vitality and libido.
Muira puama acts as an effective neuroprotective agent: it helps protect brain cells (neurons) from damage and supports the quality of nerve impulse transmission. It is also considered one of the few natural remedies that can activate the so-called nerve growth factor in the central and peripheral nervous systems. Muira puama is often used to support cognitive function and to help prevent dementia, including in Alzheimer’s and Parkinson’s disease.
Muira puama is also known as a mild central nervous system stimulant and is used in cases of increased anxiety, low mood, stress, and sleep disturbances.
These two trees are also used together to boost vitality and libido.
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Muira Puama / Marapuama (Ptychopetalum olacoides)
Catuaba (Trichilia catigua)
Muira Puama (muira puama), or Marapuama (marapuama), is a small tree that grows in the tropical forests of the Amazon basin. It is also called the “tree of power” because it contains a large number of biologically active substances, including alkaloids (the main one is muirapuamine), esters of triterpene acids and phytosterols, tannins, essential and fatty oils, fatty acids, coumarin, flavonoids, and saponins.
Since ancient times, the indigenous peoples of South America have used Muira Puama to increase physical activity and to address sexual weakness. In Brazilian herbal medicine, Muira Puama has a reputation as a powerful aphrodisiac and is also taken as a tonic to enhance physical and mental performance, especially during periods of stress.
Studying the potential of this plant to treat and improve neurodegenerative conditions, researchers note that its active compounds may have a positive effect on the central nervous system, help reduce depressive states, and provide nootropic, adaptogenic, and neuroprotective effects.
Since ancient times, the indigenous peoples of South America have used Muira Puama to increase physical activity and to address sexual weakness. In Brazilian herbal medicine, Muira Puama has a reputation as a powerful aphrodisiac and is also taken as a tonic to enhance physical and mental performance, especially during periods of stress.
Studying the potential of this plant to treat and improve neurodegenerative conditions, researchers note that its active compounds may have a positive effect on the central nervous system, help reduce depressive states, and provide nootropic, adaptogenic, and neuroprotective effects.
Under the general name Catuaba, several plant species with similar properties—but varying effectiveness—are used in South America. For the production of MARATUABA®, we use Trichilia catigua, a small tree distributed in Bolivia, northern Argentina, and in the cerrado and Atlantic forests of Brazil.
The list of biologically active compounds found in Catuaba includes alkaloids, tannins, and phytosterols, including β-sitosterol; epicatechins (catiguanin A and catiguanin B); and four flavolignans extracted from the bark of T. catigua: cinchonain-Ia, cinchonain-Ib, cinchonain-Ic, and cinchonain-Id.
In North and South America, Catuaba is widely used as a cardiotonic, as a stimulant for mental fatigue, during physical training, and for sleep disturbances, fatigue, and decreased libido. It is noted that under conditions of increased nervous tension, Catuaba acts as an adaptogen, helping improve physical and cognitive functions and stimulating sexual activity.
During studies of the plant, scientists found that an extract prepared from the bark of T. catigua has antidepressant, antioxidant, antinociceptive, and vasorelaxant properties, and that these effects are associated with the release of nitric oxide and nitric oxide–derived compounds.
It is worth noting that nitric oxide is a naturally occurring gas that promotes vascular elasticity and dilation, increases blood oxygenation, helps prevent blood clot formation, and reduces the harmful effects of stress hormones. Nitric oxide has been shown to have a beneficial effect on erectile function and to stimulate testosterone production, which may contribute to muscle growth and improved strength performance during sports.
In North and South America, Catuaba is widely used as a cardiotonic, as a stimulant for mental fatigue, during physical training, and for sleep disturbances, fatigue, and decreased libido. It is noted that under conditions of increased nervous tension, Catuaba acts as an adaptogen, helping improve physical and cognitive functions and stimulating sexual activity.
During studies of the plant, scientists found that an extract prepared from the bark of T. catigua has antidepressant, antioxidant, antinociceptive, and vasorelaxant properties, and that these effects are associated with the release of nitric oxide and nitric oxide–derived compounds.
It is worth noting that nitric oxide is a naturally occurring gas that promotes vascular elasticity and dilation, increases blood oxygenation, helps prevent blood clot formation, and reduces the harmful effects of stress hormones. Nitric oxide has been shown to have a beneficial effect on erectile function and to stimulate testosterone production, which may contribute to muscle growth and improved strength performance during sports.
Muira Puama / Marapuama (Ptychopetalum olacoides)
Catuaba (Trichilia catigua)
Muira Puama (muira puama), or Marapuama (marapuama), is a small tree that grows in the tropical forests of the Amazon basin. It is also called the “tree of power” because it contains a large number of biologically active substances, including alkaloids (the main one is muirapuamine), esters of triterpene acids and phytosterols, tannins, essential and fatty oils, fatty acids, coumarin, flavonoids, and saponins.
Since ancient times, the indigenous peoples of South America have used Muira Puama to increase physical activity and to address sexual weakness. In Brazilian herbal medicine, Muira Puama has a reputation as a powerful aphrodisiac and is also taken as a tonic to enhance physical and mental performance, especially during periods of stress.
Studying the potential of this plant to treat and improve neurodegenerative conditions, researchers note that its active compounds may have a positive effect on the central nervous system, help reduce depressive states, and provide nootropic, adaptogenic, and neuroprotective effects.
Since ancient times, the indigenous peoples of South America have used Muira Puama to increase physical activity and to address sexual weakness. In Brazilian herbal medicine, Muira Puama has a reputation as a powerful aphrodisiac and is also taken as a tonic to enhance physical and mental performance, especially during periods of stress.
Studying the potential of this plant to treat and improve neurodegenerative conditions, researchers note that its active compounds may have a positive effect on the central nervous system, help reduce depressive states, and provide nootropic, adaptogenic, and neuroprotective effects.
Under the general name Catuaba, several plant species with similar properties—but varying effectiveness—are used in South America. For the production of MARATUABA®, we use Trichilia catigua, a small tree distributed in Bolivia, northern Argentina, and in the cerrado and Atlantic forests of Brazil.
The list of biologically active compounds found in Catuaba includes alkaloids, tannins, and phytosterols, including β-sitosterol; epicatechins (catiguanin A and catiguanin B); and four flavolignans extracted from the bark of T. catigua: cinchonain-Ia, cinchonain-Ib, cinchonain-Ic, and cinchonain-Id.
In North and South America, Catuaba is widely used as a cardiotonic, as a stimulant for mental fatigue, during physical training, and for sleep disturbances, fatigue, and decreased libido. It is noted that under conditions of increased nervous tension, Catuaba acts as an adaptogen, helping improve physical and cognitive functions and stimulating sexual activity.
During studies of the plant, scientists found that an extract prepared from the bark of T. catigua has antidepressant, antioxidant, antinociceptive, and vasorelaxant properties, and that these effects are associated with the release of nitric oxide and nitric oxide–derived compounds.
It is worth noting that nitric oxide is a naturally occurring gas that promotes vascular elasticity and dilation, increases blood oxygenation, helps prevent blood clot formation, and reduces the harmful effects of stress hormones. Nitric oxide has been shown to have a beneficial effect on erectile function and to stimulate testosterone production, which may contribute to muscle growth and improved strength performance during sports.
In North and South America, Catuaba is widely used as a cardiotonic, as a stimulant for mental fatigue, during physical training, and for sleep disturbances, fatigue, and decreased libido. It is noted that under conditions of increased nervous tension, Catuaba acts as an adaptogen, helping improve physical and cognitive functions and stimulating sexual activity.
During studies of the plant, scientists found that an extract prepared from the bark of T. catigua has antidepressant, antioxidant, antinociceptive, and vasorelaxant properties, and that these effects are associated with the release of nitric oxide and nitric oxide–derived compounds.
It is worth noting that nitric oxide is a naturally occurring gas that promotes vascular elasticity and dilation, increases blood oxygenation, helps prevent blood clot formation, and reduces the harmful effects of stress hormones. Nitric oxide has been shown to have a beneficial effect on erectile function and to stimulate testosterone production, which may contribute to muscle growth and improved strength performance during sports.
Sources
1. Tang W., Kubo M., Harada K., Hioki H., Fukuyama Y. Novel NGF-potentiating diterpe-noids from a Brazilian medicinal plant, Ptychopetalum olacoides. // Bioorg. Med. Chem. Lett. 2009, 19(3), рр.882-886.
2. Tang W., Harada K., Kubo M., Hioki H., Fukuyama Y. Eight new clerodane diterpenoids from the bark of Ptychopetalum olacoides. // Nat. Prod. Commun. 2011, 6(3), рр.327-332.
3. Taylor L. The Healing Power of Rainforest Herbs. Square One Publishers, INC. 2005, 535рр.
2. Tang W., Harada K., Kubo M., Hioki H., Fukuyama Y. Eight new clerodane diterpenoids from the bark of Ptychopetalum olacoides. // Nat. Prod. Commun. 2011, 6(3), рр.327-332.
3. Taylor L. The Healing Power of Rainforest Herbs. Square One Publishers, INC. 2005, 535рр.
Sources
1. Tang W., Kubo M., Harada K., Hioki H., Fukuyama Y. Novel NGF-potentiating diterpe-noids from a Brazilian medicinal plant, Ptychopetalum olacoides. // Bioorg. Med. Chem. Lett. 2009, 19(3), рр.882-886.
2. Tang W., Harada K., Kubo M., Hioki H., Fukuyama Y. Eight new clerodane diterpenoids from the bark of Ptychopetalum olacoides. // Nat. Prod. Commun. 2011, 6(3), рр.327-332.
3. Taylor L. The Healing Power of Rainforest Herbs. Square One Publishers, INC. 2005, 535рр.4. Farmacopéia Brasileira, 1926
5. R. Shamloul, “Natural aphrodisiacs,” Journal of SexualMedicine, vol. 7, no. 1, pp. 39–49, 2010
6. I.R. Siqueira,D.R. Lara,D. Silva,F.S. Gaieski,D.S. Nunes &E. Elisabetsky. Psychopharmacological Properties of Ptychopetalum Olacoides bentham (Olacaceae) // ISSN: 1388-0209 (Print) 1744-5116 (Online) Journal homepage: https://www.tandfonline.com/loi/iphb20
7. Gaurang R Shah, Manojkumar V Chaudhari, Suresh B Patankar, Shrikant V Pensalwar4, Vilas P Sabale, Navneet A Sonawane. Evaluation of a multi-herb supplement for erectile dysfunction: a randomized double-blind,placebo-controlled study// Shah et al. BMC Complementary and Alternative Medicine 2012, 12:155, http://www.biomedcentral.com/1472-6882/12/155
8. СГР № RU.77.99.11.003.Е.014096.04.11 от 08.04.2011
9. J. Waynberg, “Yohimbine vs. muira puama in the treatment of sexual dysfunction,”The American Journal of Natural Medicine, vol. 1, pp. 8–9, 1994.
10. Tobias S. Köhler, Kevin T. McVary. Contemporary Treatment of Erectile Dysfunction: A Clinical Guide, p. 144//Springer, 2016. ISBN 3319315870, 9783319315874
11. Mendes FR, Carlini EA, Brazilian plants as possible adaptogens: an ethnopharmacological survey ofbooks edited in Brazil, Journal of Ethnopharmacology, 2007, 109(3), 493-500
12. Piato AL, Rizon LP, Martins BS, Nunes DS, Elisabetsky E (2009) Antidepressant profile of Ptychopetalum
olacoides Bentham (Marapuama) in mice. Phytother Res 23(4):519–524
13. A.L. Piato, B.C. Detanico, V.M. Linck, A.P. Herrmann, D.S. Nunes, E Elisabetsky. Anti-stress effects of the
"tonic"Ptychopetalum olacoides (Marapuama) in mice // Phytomedicine. 2010 Mar;17(3-4):248-53.
14. I.R. Siqueira, C Fochesatto, I L S Torres, A L da Silva, D S Nunes, E Elisabetsky, C A Netto. Antioxidant activities
of Ptychopetalum olacoides ("muirapuama") in mice brain // Phytomedicine. 2007 Nov;14(11):763-9. doi: 10.1016/j.phymed.2006.12.007. Epub 2007 Apr 12.
15. Figueiró M, Ilha J, Linck VM, Herrmann AP, Nardin P, Menezes CB, Achaval M, Gonçalves CA, Porciúncula LO,
Nunes DS, Elisabetsky E. The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse
Alzheimer model. Phytomedicine. 2011 Feb 15;18(4):327-33. doi: 10.1016/j.phymed.2010.07.013. Epub 2010 Aug 23.
16. Figueiró M, Ilha J, etc. Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a
nootropic Amazonian herbal (Marapuama) // Phytomedicine, 2010 Oct;17(12):956-62.
17. da Silva AL, Piato AL, Bardini S, Netto CA, Nunes DS, Elisabetsky E Memory retrieval improvement by
Ptychopetalum olacoides in young and aging mice.// J. Ethnopharmacol. 2004 Dec;95(2-3):199-203. doi:
10.1016/j.jep.2004.07.019.PMID: 15507336
18. da Silva AL, Piato AL, Ferreira JG, Martins BS, Nunes DS, Elisabetsky E. Promnesic effects of Ptychopetalum
olacoides in aversive and non-aversive learning paradigms.// J Ethnopharmacol. 2007 Feb 12;109(3):449-57. doi: 10.1016/j.jep.2006.08.022. Epub 2006 Aug 30.PMID: 17023132
19. da Silva AL, Ferreira JG, da Silva Martins B, Oliveira S, Mai N, Nunes DS, Elisabetsky E. Serotonin receptors
contribute to the promnesic effects of P. olacoides (Marapuama). // Physiol Behav. 2008 Sep 3;95(1-2):88-92. doi: 10.1016/j.physbeh.2008.04.022. Epub 2008 May 1.PMID: 18561960
20. da Silva AL, Silva Martins Bd, Linck Vde M, Herrmann AP, Mai N, Nunes DS, Elisabetsky E. MK801- and
scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a "brain tonic".
21. Beltrame FL, Filho ER, Barros FA, Cortez DA, Cass QB, A validated higher-performance liquid chromatography
method for quantification of cinchonain Ib in bark and phytopharmaceuticals of Trichilia catigua used as Catuaba, Journal of
Chromatography, 2006,1119(1-2), 257-263;
22. Boquett Lagos J., Bruel Gemin C.A., de Fátima Gaspari Dias J., Dallarmi Miguel M., Campos R., de Souza
Carvalho J.L., do Rocio Duarte M. Gomes M.O. Contribution to the Study of Phytosterols and Phenolics from the Barks and Leaves of
the Trichilia catigua A. Juss., Meliaceae // Journal of Analytical Sciences, Methods and Instrumentation, 2012, 2, 37-41
23. Tang W., Hioki H., Harada K., Kubo M., Fukuyama Y. Antioxidant phenylpropanoid-substituted epicatechins from Trichilia catigua. // J. Nat. Prod. 2007, 70(12), рр.2010-2013.
24. Rafael C. Dutra, Maria M. Camposc, Adair R.S. Santos, João B. Calixto. Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives // Pharmacological Research 112 (2016) 4–29
25. Longhini R, Lonni AASG, Sereia AL, Krzyzaniak LM, Lopes GC, de Mello JCP. Trichilia catigua: therapeutic and
cosmetic values. Braz J Pharmacogn. 2017;27:254–71;
26. Kamdem JP, Olalekan EO, Hassan W, Kade IJ, Yetunde O, Boligon AA, Athayde ML, Souza DO, Rocha JBT. Trichilia
catigua (Catuaba) bark extract exerts neuroprotection against oxidative stress induced by different neurotoxic agents in rat hippocampal
slices. Ind Crop Prod. 2013;50:625–32;
27. Chassot JM, Longhini R, Gazarini L, Mello JCP, De Oliveira RMW. Preclinical evaluation of Trichilia catigua extracts on
the central nervous system of mice. J Ethnopharmacol. 2011;137:1143–8;
28. Martins NO, de Brito IM, Araujo SSO, Negri G, Carlini EA, Mendes FR (2018) Antioxidant, anticholinesterase and
antifatigue effects of Trichilia catigua (catuaba). BMC Complement Alternat Med 18:172.
29. Kletter C, Glasi S, Presser A, Werner I, Reznicek G etal, Morphological, chemical and functional analysis of catuaba
preparations, Planta Medica, 2004, 70(10), 993-1000.
30. Mendes FR, Carlini EA, Brazilian plants as possible adaptogens: an ethnopharmacological survey of books edited in
Brazil, Journal of Ethnopharmacology, 2007, 109(3), 493-500;
31. Chassot JM, Longhini R, Gazarini L, Mello JC, de Oliveira RM, Preclinical evaluation of Trichilia catigua extracts on the central nervous system of mice, Journal of Ethnopharmacology, 2011, 137(3), 1143-1148.
32. Viana AF, Maciel IS, Motta EM, Leal PC, Pianowski L, Campos MM, Calixto JB. Antinociceptive activity of Trichilia catigua hydroalcoholic extract: new evidence on its dopaminergic effects. Evidence-based Complement Altern Med. 2011;
33. Truiti M.T., Soares L., Longhini R., Milani H., Nakamura C.V., Mello J.C., de Oliveira R.M. Trichilia catigua ethyl-acetate
fraction protects against cognitive impairments and hippocampal cell death induced by bilateral common carotid occlusion in mice. // J.
Ethnopharmacol. 2015, 172, рр.232-237;
34. Campos MM, Fernandes ES, Ferreira J, Santos ARS, Calixto JB. Antidepressant-like effects of Trichilia catigua
(Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology (Berl). 2005;182:45–53.
35. Viana AF, Maciel IS, Motta EM, Leal PC, Pianowski L, Campos MM, Calixto JB. Antinociceptive activity of Trichilia catigua hydroalcoholic extract: new evidence on its dopaminergic effects. Evidence-based Complement Altern Med. 2011
36. Patent Publication Number WO/1999/002172. Publication Date21.01.1999. PHARMACEUTICAL FORMULATIONS
COMPRISING VEGETAL MATERIAL SELECTED FROM TRICHILIA.
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO1999002172&tab=PCTDESCRIPTION
37. Патентные описания к заявкам WO2007016756A1 https://patents.google.com/patent/WO2007016756A1/en и DE10140320A1 https://patents.google.com/patent/DE10140320A1/en
38. Oliveira C.H., Moraes M.E., Moraes M.O., Bezerra F.A., Abib E., De Nucci G. Clinical toxicology study of an herbal
medicinal extract of Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides and Zingiber officinale (Catuama) in healthy volunteers.
// Phytother. Res. 2005, 19(1), рр.54-57.
39. Calixto, J.B., Cabrini, D.A., 1997. Herbal medicine Catuama induces endothelium-dependent and -independent vasorelaxant action on isolated vessels from rats,guinea-pigs and rabbits. Phytother. Res. 11, 32–38.
40. Ахвледиани, Н.Д. Эректильная дисфункция: современное состояние проблемы / Н. Д. Ахвледиани, С. Н. Алленов и др. // Медицинский совет. – 2015. – Вып. 2. – С. 28–32.
41. E. Antunes, W.M. Gordo, J.F. Oliveira, C.E. Teixeira, S. Hyslop, G. NucciThe relaxation of isolated rabbit corpus
cavernosum by the herbal medicine Catuama® and its constituents. Phytother. Res., 15 (2001), pp. 416-421
42. Longhini R, Lonni AASG, Sereia AL, Krzyzaniak LM, Lopes GC, de Mello JCP. Trichilia catigua: therapeutic and
cosmetic values. Braz J Pharmacogn. 2017;27:254–71
5. R. Shamloul, “Natural aphrodisiacs,” Journal of SexualMedicine, vol. 7, no. 1, pp. 39–49, 2010
6. I.R. Siqueira,D.R. Lara,D. Silva,F.S. Gaieski,D.S. Nunes &E. Elisabetsky. Psychopharmacological Properties of Ptychopetalum Olacoides bentham (Olacaceae) // ISSN: 1388-0209 (Print) 1744-5116 (Online) Journal homepage: https://www.tandfonline.com/loi/iphb20
7. Gaurang R Shah, Manojkumar V Chaudhari, Suresh B Patankar, Shrikant V Pensalwar4, Vilas P Sabale, Navneet A Sonawane. Evaluation of a multi-herb supplement for erectile dysfunction: a randomized double-blind,placebo-controlled study// Shah et al. BMC Complementary and Alternative Medicine 2012, 12:155, http://www.biomedcentral.com/1472-6882/12/155
8. СГР № RU.77.99.11.003.Е.014096.04.11 от 08.04.2011
9. J. Waynberg, “Yohimbine vs. muira puama in the treatment of sexual dysfunction,”The American Journal of Natural Medicine, vol. 1, pp. 8–9, 1994.
10. Tobias S. Köhler, Kevin T. McVary. Contemporary Treatment of Erectile Dysfunction: A Clinical Guide, p. 144//Springer, 2016. ISBN 3319315870, 9783319315874
11. Mendes FR, Carlini EA, Brazilian plants as possible adaptogens: an ethnopharmacological survey ofbooks edited in Brazil, Journal of Ethnopharmacology, 2007, 109(3), 493-500
12. Piato AL, Rizon LP, Martins BS, Nunes DS, Elisabetsky E (2009) Antidepressant profile of Ptychopetalum
olacoides Bentham (Marapuama) in mice. Phytother Res 23(4):519–524
13. A.L. Piato, B.C. Detanico, V.M. Linck, A.P. Herrmann, D.S. Nunes, E Elisabetsky. Anti-stress effects of the
"tonic"Ptychopetalum olacoides (Marapuama) in mice // Phytomedicine. 2010 Mar;17(3-4):248-53.
14. I.R. Siqueira, C Fochesatto, I L S Torres, A L da Silva, D S Nunes, E Elisabetsky, C A Netto. Antioxidant activities
of Ptychopetalum olacoides ("muirapuama") in mice brain // Phytomedicine. 2007 Nov;14(11):763-9. doi: 10.1016/j.phymed.2006.12.007. Epub 2007 Apr 12.
15. Figueiró M, Ilha J, Linck VM, Herrmann AP, Nardin P, Menezes CB, Achaval M, Gonçalves CA, Porciúncula LO,
Nunes DS, Elisabetsky E. The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse
Alzheimer model. Phytomedicine. 2011 Feb 15;18(4):327-33. doi: 10.1016/j.phymed.2010.07.013. Epub 2010 Aug 23.
16. Figueiró M, Ilha J, etc. Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a
nootropic Amazonian herbal (Marapuama) // Phytomedicine, 2010 Oct;17(12):956-62.
17. da Silva AL, Piato AL, Bardini S, Netto CA, Nunes DS, Elisabetsky E Memory retrieval improvement by
Ptychopetalum olacoides in young and aging mice.// J. Ethnopharmacol. 2004 Dec;95(2-3):199-203. doi:
10.1016/j.jep.2004.07.019.PMID: 15507336
18. da Silva AL, Piato AL, Ferreira JG, Martins BS, Nunes DS, Elisabetsky E. Promnesic effects of Ptychopetalum
olacoides in aversive and non-aversive learning paradigms.// J Ethnopharmacol. 2007 Feb 12;109(3):449-57. doi: 10.1016/j.jep.2006.08.022. Epub 2006 Aug 30.PMID: 17023132
19. da Silva AL, Ferreira JG, da Silva Martins B, Oliveira S, Mai N, Nunes DS, Elisabetsky E. Serotonin receptors
contribute to the promnesic effects of P. olacoides (Marapuama). // Physiol Behav. 2008 Sep 3;95(1-2):88-92. doi: 10.1016/j.physbeh.2008.04.022. Epub 2008 May 1.PMID: 18561960
20. da Silva AL, Silva Martins Bd, Linck Vde M, Herrmann AP, Mai N, Nunes DS, Elisabetsky E. MK801- and
scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a "brain tonic".
21. Beltrame FL, Filho ER, Barros FA, Cortez DA, Cass QB, A validated higher-performance liquid chromatography
method for quantification of cinchonain Ib in bark and phytopharmaceuticals of Trichilia catigua used as Catuaba, Journal of
Chromatography, 2006,1119(1-2), 257-263;
22. Boquett Lagos J., Bruel Gemin C.A., de Fátima Gaspari Dias J., Dallarmi Miguel M., Campos R., de Souza
Carvalho J.L., do Rocio Duarte M. Gomes M.O. Contribution to the Study of Phytosterols and Phenolics from the Barks and Leaves of
the Trichilia catigua A. Juss., Meliaceae // Journal of Analytical Sciences, Methods and Instrumentation, 2012, 2, 37-41
23. Tang W., Hioki H., Harada K., Kubo M., Fukuyama Y. Antioxidant phenylpropanoid-substituted epicatechins from Trichilia catigua. // J. Nat. Prod. 2007, 70(12), рр.2010-2013.
24. Rafael C. Dutra, Maria M. Camposc, Adair R.S. Santos, João B. Calixto. Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives // Pharmacological Research 112 (2016) 4–29
25. Longhini R, Lonni AASG, Sereia AL, Krzyzaniak LM, Lopes GC, de Mello JCP. Trichilia catigua: therapeutic and
cosmetic values. Braz J Pharmacogn. 2017;27:254–71;
26. Kamdem JP, Olalekan EO, Hassan W, Kade IJ, Yetunde O, Boligon AA, Athayde ML, Souza DO, Rocha JBT. Trichilia
catigua (Catuaba) bark extract exerts neuroprotection against oxidative stress induced by different neurotoxic agents in rat hippocampal
slices. Ind Crop Prod. 2013;50:625–32;
27. Chassot JM, Longhini R, Gazarini L, Mello JCP, De Oliveira RMW. Preclinical evaluation of Trichilia catigua extracts on
the central nervous system of mice. J Ethnopharmacol. 2011;137:1143–8;
28. Martins NO, de Brito IM, Araujo SSO, Negri G, Carlini EA, Mendes FR (2018) Antioxidant, anticholinesterase and
antifatigue effects of Trichilia catigua (catuaba). BMC Complement Alternat Med 18:172.
29. Kletter C, Glasi S, Presser A, Werner I, Reznicek G etal, Morphological, chemical and functional analysis of catuaba
preparations, Planta Medica, 2004, 70(10), 993-1000.
30. Mendes FR, Carlini EA, Brazilian plants as possible adaptogens: an ethnopharmacological survey of books edited in
Brazil, Journal of Ethnopharmacology, 2007, 109(3), 493-500;
31. Chassot JM, Longhini R, Gazarini L, Mello JC, de Oliveira RM, Preclinical evaluation of Trichilia catigua extracts on the central nervous system of mice, Journal of Ethnopharmacology, 2011, 137(3), 1143-1148.
32. Viana AF, Maciel IS, Motta EM, Leal PC, Pianowski L, Campos MM, Calixto JB. Antinociceptive activity of Trichilia catigua hydroalcoholic extract: new evidence on its dopaminergic effects. Evidence-based Complement Altern Med. 2011;
33. Truiti M.T., Soares L., Longhini R., Milani H., Nakamura C.V., Mello J.C., de Oliveira R.M. Trichilia catigua ethyl-acetate
fraction protects against cognitive impairments and hippocampal cell death induced by bilateral common carotid occlusion in mice. // J.
Ethnopharmacol. 2015, 172, рр.232-237;
34. Campos MM, Fernandes ES, Ferreira J, Santos ARS, Calixto JB. Antidepressant-like effects of Trichilia catigua
(Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology (Berl). 2005;182:45–53.
35. Viana AF, Maciel IS, Motta EM, Leal PC, Pianowski L, Campos MM, Calixto JB. Antinociceptive activity of Trichilia catigua hydroalcoholic extract: new evidence on its dopaminergic effects. Evidence-based Complement Altern Med. 2011
36. Patent Publication Number WO/1999/002172. Publication Date21.01.1999. PHARMACEUTICAL FORMULATIONS
COMPRISING VEGETAL MATERIAL SELECTED FROM TRICHILIA.
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO1999002172&tab=PCTDESCRIPTION
37. Патентные описания к заявкам WO2007016756A1 https://patents.google.com/patent/WO2007016756A1/en и DE10140320A1 https://patents.google.com/patent/DE10140320A1/en
38. Oliveira C.H., Moraes M.E., Moraes M.O., Bezerra F.A., Abib E., De Nucci G. Clinical toxicology study of an herbal
medicinal extract of Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides and Zingiber officinale (Catuama) in healthy volunteers.
// Phytother. Res. 2005, 19(1), рр.54-57.
39. Calixto, J.B., Cabrini, D.A., 1997. Herbal medicine Catuama induces endothelium-dependent and -independent vasorelaxant action on isolated vessels from rats,guinea-pigs and rabbits. Phytother. Res. 11, 32–38.
40. Ахвледиани, Н.Д. Эректильная дисфункция: современное состояние проблемы / Н. Д. Ахвледиани, С. Н. Алленов и др. // Медицинский совет. – 2015. – Вып. 2. – С. 28–32.
41. E. Antunes, W.M. Gordo, J.F. Oliveira, C.E. Teixeira, S. Hyslop, G. NucciThe relaxation of isolated rabbit corpus
cavernosum by the herbal medicine Catuama® and its constituents. Phytother. Res., 15 (2001), pp. 416-421
42. Longhini R, Lonni AASG, Sereia AL, Krzyzaniak LM, Lopes GC, de Mello JCP. Trichilia catigua: therapeutic and
cosmetic values. Braz J Pharmacogn. 2017;27:254–71
4. Farmacopéia Brasileira, 1926
5. R. Shamloul, “Natural aphrodisiacs,” Journal of SexualMedicine, vol. 7, no. 1, pp. 39–49, 2010
6. I.R. Siqueira,D.R. Lara,D. Silva,F.S. Gaieski,D.S. Nunes &E. Elisabetsky. Psychopharmacological Properties of Ptychopetalum Olacoides bentham (Olacaceae) // ISSN: 1388-0209 (Print) 1744-5116 (Online) Journal homepage: https://www.tandfonline.com/loi/iphb20
7. Gaurang R Shah, Manojkumar V Chaudhari, Suresh B Patankar, Shrikant V Pensalwar4, Vilas P Sabale, Navneet A Sonawane. Evaluation of a multi-herb supplement for erectile dysfunction: a randomized double-blind,placebo-controlled study// Shah et al. BMC Complementary and Alternative Medicine 2012, 12:155, http://www.biomedcentral.com/1472-6882/12/155
8. СГР № RU.77.99.11.003.Е.014096.04.11 от 08.04.2011
9. J. Waynberg, “Yohimbine vs. muira puama in the treatment of sexual dysfunction,”The American Journal of Natural Medicine, vol. 1, pp. 8–9, 1994.
10. Tobias S. Köhler, Kevin T. McVary. Contemporary Treatment of Erectile Dysfunction: A Clinical Guide, p. 144//Springer, 2016. ISBN 3319315870, 9783319315874
11. Mendes FR, Carlini EA, Brazilian plants as possible adaptogens: an ethnopharmacological survey ofbooks edited in Brazil, Journal of Ethnopharmacology, 2007, 109(3), 493-500
12. Piato AL, Rizon LP, Martins BS, Nunes DS, Elisabetsky E (2009) Antidepressant profile of Ptychopetalum
olacoides Bentham (Marapuama) in mice. Phytother Res 23(4):519–524
13. A.L. Piato, B.C. Detanico, V.M. Linck, A.P. Herrmann, D.S. Nunes, E Elisabetsky. Anti-stress effects of the
"tonic"Ptychopetalum olacoides (Marapuama) in mice // Phytomedicine. 2010 Mar;17(3-4):248-53.
14. I.R. Siqueira, C Fochesatto, I L S Torres, A L da Silva, D S Nunes, E Elisabetsky, C A Netto. Antioxidant activities
of Ptychopetalum olacoides ("muirapuama") in mice brain // Phytomedicine. 2007 Nov;14(11):763-9. doi: 10.1016/j.phymed.2006.12.007. Epub 2007 Apr 12.
15. Figueiró M, Ilha J, Linck VM, Herrmann AP, Nardin P, Menezes CB, Achaval M, Gonçalves CA, Porciúncula LO,
Nunes DS, Elisabetsky E. The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse
Alzheimer model. Phytomedicine. 2011 Feb 15;18(4):327-33. doi: 10.1016/j.phymed.2010.07.013. Epub 2010 Aug 23.
16. Figueiró M, Ilha J, etc. Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a
nootropic Amazonian herbal (Marapuama) // Phytomedicine, 2010 Oct;17(12):956-62.
17. da Silva AL, Piato AL, Bardini S, Netto CA, Nunes DS, Elisabetsky E Memory retrieval improvement by
Ptychopetalum olacoides in young and aging mice.// J. Ethnopharmacol. 2004 Dec;95(2-3):199-203. doi:
10.1016/j.jep.2004.07.019.PMID: 15507336
18. da Silva AL, Piato AL, Ferreira JG, Martins BS, Nunes DS, Elisabetsky E. Promnesic effects of Ptychopetalum
olacoides in aversive and non-aversive learning paradigms.// J Ethnopharmacol. 2007 Feb 12;109(3):449-57. doi: 10.1016/j.jep.2006.08.022. Epub 2006 Aug 30.PMID: 17023132
19. da Silva AL, Ferreira JG, da Silva Martins B, Oliveira S, Mai N, Nunes DS, Elisabetsky E. Serotonin receptors
contribute to the promnesic effects of P. olacoides (Marapuama). // Physiol Behav. 2008 Sep 3;95(1-2):88-92. doi: 10.1016/j.physbeh.2008.04.022. Epub 2008 May 1.PMID: 18561960
20. da Silva AL, Silva Martins Bd, Linck Vde M, Herrmann AP, Mai N, Nunes DS, Elisabetsky E. MK801- and
scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a "brain tonic".
21. Beltrame FL, Filho ER, Barros FA, Cortez DA, Cass QB, A validated higher-performance liquid chromatography
method for quantification of cinchonain Ib in bark and phytopharmaceuticals of Trichilia catigua used as Catuaba, Journal of
Chromatography, 2006,1119(1-2), 257-263;
22. Boquett Lagos J., Bruel Gemin C.A., de Fátima Gaspari Dias J., Dallarmi Miguel M., Campos R., de Souza
Carvalho J.L., do Rocio Duarte M. Gomes M.O. Contribution to the Study of Phytosterols and Phenolics from the Barks and Leaves of
the Trichilia catigua A. Juss., Meliaceae // Journal of Analytical Sciences, Methods and Instrumentation, 2012, 2, 37-41
23. Tang W., Hioki H., Harada K., Kubo M., Fukuyama Y. Antioxidant phenylpropanoid-substituted epicatechins from Trichilia catigua. // J. Nat. Prod. 2007, 70(12), рр.2010-2013.
24. Rafael C. Dutra, Maria M. Camposc, Adair R.S. Santos, João B. Calixto. Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives // Pharmacological Research 112 (2016) 4–29
25. Longhini R, Lonni AASG, Sereia AL, Krzyzaniak LM, Lopes GC, de Mello JCP. Trichilia catigua: therapeutic and
cosmetic values. Braz J Pharmacogn. 2017;27:254–71;
26. Kamdem JP, Olalekan EO, Hassan W, Kade IJ, Yetunde O, Boligon AA, Athayde ML, Souza DO, Rocha JBT. Trichilia
catigua (Catuaba) bark extract exerts neuroprotection against oxidative stress induced by different neurotoxic agents in rat hippocampal
slices. Ind Crop Prod. 2013;50:625–32;
27. Chassot JM, Longhini R, Gazarini L, Mello JCP, De Oliveira RMW. Preclinical evaluation of Trichilia catigua extracts on
the central nervous system of mice. J Ethnopharmacol. 2011;137:1143–8;
28. Martins NO, de Brito IM, Araujo SSO, Negri G, Carlini EA, Mendes FR (2018) Antioxidant, anticholinesterase and
antifatigue effects of Trichilia catigua (catuaba). BMC Complement Alternat Med 18:172.
29. Kletter C, Glasi S, Presser A, Werner I, Reznicek G etal, Morphological, chemical and functional analysis of catuaba
preparations, Planta Medica, 2004, 70(10), 993-1000.
30. Mendes FR, Carlini EA, Brazilian plants as possible adaptogens: an ethnopharmacological survey of books edited in
Brazil, Journal of Ethnopharmacology, 2007, 109(3), 493-500;
31. Chassot JM, Longhini R, Gazarini L, Mello JC, de Oliveira RM, Preclinical evaluation of Trichilia catigua extracts on the central nervous system of mice, Journal of Ethnopharmacology, 2011, 137(3), 1143-1148.
32. Viana AF, Maciel IS, Motta EM, Leal PC, Pianowski L, Campos MM, Calixto JB. Antinociceptive activity of Trichilia catigua hydroalcoholic extract: new evidence on its dopaminergic effects. Evidence-based Complement Altern Med. 2011;
33. Truiti M.T., Soares L., Longhini R., Milani H., Nakamura C.V., Mello J.C., de Oliveira R.M. Trichilia catigua ethyl-acetate
fraction protects against cognitive impairments and hippocampal cell death induced by bilateral common carotid occlusion in mice. // J.
Ethnopharmacol. 2015, 172, рр.232-237;
34. Campos MM, Fernandes ES, Ferreira J, Santos ARS, Calixto JB. Antidepressant-like effects of Trichilia catigua
(Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology (Berl). 2005;182:45–53.
35. Viana AF, Maciel IS, Motta EM, Leal PC, Pianowski L, Campos MM, Calixto JB. Antinociceptive activity of Trichilia catigua hydroalcoholic extract: new evidence on its dopaminergic effects. Evidence-based Complement Altern Med. 2011
36. Patent Publication Number WO/1999/002172. Publication Date21.01.1999. PHARMACEUTICAL FORMULATIONS
COMPRISING VEGETAL MATERIAL SELECTED FROM TRICHILIA.
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO1999002172&tab=PCTDESCRIPTION
37. Патентные описания к заявкам WO2007016756A1 https://patents.google.com/patent/WO2007016756A1/en и DE10140320A1 https://patents.google.com/patent/DE10140320A1/en
38. Oliveira C.H., Moraes M.E., Moraes M.O., Bezerra F.A., Abib E., De Nucci G. Clinical toxicology study of an herbal
medicinal extract of Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides and Zingiber officinale (Catuama) in healthy volunteers.
// Phytother. Res. 2005, 19(1), рр.54-57.
39. Calixto, J.B., Cabrini, D.A., 1997. Herbal medicine Catuama induces endothelium-dependent and -independent vasorelaxant action on isolated vessels from rats,guinea-pigs and rabbits. Phytother. Res. 11, 32–38.
40. Ахвледиани, Н.Д. Эректильная дисфункция: современное состояние проблемы / Н. Д. Ахвледиани, С. Н. Алленов и др. // Медицинский совет. – 2015. – Вып. 2. – С. 28–32.
41. E. Antunes, W.M. Gordo, J.F. Oliveira, C.E. Teixeira, S. Hyslop, G. NucciThe relaxation of isolated rabbit corpus
cavernosum by the herbal medicine Catuama® and its constituents. Phytother. Res., 15 (2001), pp. 416-421
42. Longhini R, Lonni AASG, Sereia AL, Krzyzaniak LM, Lopes GC, de Mello JCP. Trichilia catigua: therapeutic and
cosmetic values. Braz J Pharmacogn. 2017;27:254–71
5. R. Shamloul, “Natural aphrodisiacs,” Journal of SexualMedicine, vol. 7, no. 1, pp. 39–49, 2010
6. I.R. Siqueira,D.R. Lara,D. Silva,F.S. Gaieski,D.S. Nunes &E. Elisabetsky. Psychopharmacological Properties of Ptychopetalum Olacoides bentham (Olacaceae) // ISSN: 1388-0209 (Print) 1744-5116 (Online) Journal homepage: https://www.tandfonline.com/loi/iphb20
7. Gaurang R Shah, Manojkumar V Chaudhari, Suresh B Patankar, Shrikant V Pensalwar4, Vilas P Sabale, Navneet A Sonawane. Evaluation of a multi-herb supplement for erectile dysfunction: a randomized double-blind,placebo-controlled study// Shah et al. BMC Complementary and Alternative Medicine 2012, 12:155, http://www.biomedcentral.com/1472-6882/12/155
8. СГР № RU.77.99.11.003.Е.014096.04.11 от 08.04.2011
9. J. Waynberg, “Yohimbine vs. muira puama in the treatment of sexual dysfunction,”The American Journal of Natural Medicine, vol. 1, pp. 8–9, 1994.
10. Tobias S. Köhler, Kevin T. McVary. Contemporary Treatment of Erectile Dysfunction: A Clinical Guide, p. 144//Springer, 2016. ISBN 3319315870, 9783319315874
11. Mendes FR, Carlini EA, Brazilian plants as possible adaptogens: an ethnopharmacological survey ofbooks edited in Brazil, Journal of Ethnopharmacology, 2007, 109(3), 493-500
12. Piato AL, Rizon LP, Martins BS, Nunes DS, Elisabetsky E (2009) Antidepressant profile of Ptychopetalum
olacoides Bentham (Marapuama) in mice. Phytother Res 23(4):519–524
13. A.L. Piato, B.C. Detanico, V.M. Linck, A.P. Herrmann, D.S. Nunes, E Elisabetsky. Anti-stress effects of the
"tonic"Ptychopetalum olacoides (Marapuama) in mice // Phytomedicine. 2010 Mar;17(3-4):248-53.
14. I.R. Siqueira, C Fochesatto, I L S Torres, A L da Silva, D S Nunes, E Elisabetsky, C A Netto. Antioxidant activities
of Ptychopetalum olacoides ("muirapuama") in mice brain // Phytomedicine. 2007 Nov;14(11):763-9. doi: 10.1016/j.phymed.2006.12.007. Epub 2007 Apr 12.
15. Figueiró M, Ilha J, Linck VM, Herrmann AP, Nardin P, Menezes CB, Achaval M, Gonçalves CA, Porciúncula LO,
Nunes DS, Elisabetsky E. The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse
Alzheimer model. Phytomedicine. 2011 Feb 15;18(4):327-33. doi: 10.1016/j.phymed.2010.07.013. Epub 2010 Aug 23.
16. Figueiró M, Ilha J, etc. Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a
nootropic Amazonian herbal (Marapuama) // Phytomedicine, 2010 Oct;17(12):956-62.
17. da Silva AL, Piato AL, Bardini S, Netto CA, Nunes DS, Elisabetsky E Memory retrieval improvement by
Ptychopetalum olacoides in young and aging mice.// J. Ethnopharmacol. 2004 Dec;95(2-3):199-203. doi:
10.1016/j.jep.2004.07.019.PMID: 15507336
18. da Silva AL, Piato AL, Ferreira JG, Martins BS, Nunes DS, Elisabetsky E. Promnesic effects of Ptychopetalum
olacoides in aversive and non-aversive learning paradigms.// J Ethnopharmacol. 2007 Feb 12;109(3):449-57. doi: 10.1016/j.jep.2006.08.022. Epub 2006 Aug 30.PMID: 17023132
19. da Silva AL, Ferreira JG, da Silva Martins B, Oliveira S, Mai N, Nunes DS, Elisabetsky E. Serotonin receptors
contribute to the promnesic effects of P. olacoides (Marapuama). // Physiol Behav. 2008 Sep 3;95(1-2):88-92. doi: 10.1016/j.physbeh.2008.04.022. Epub 2008 May 1.PMID: 18561960
20. da Silva AL, Silva Martins Bd, Linck Vde M, Herrmann AP, Mai N, Nunes DS, Elisabetsky E. MK801- and
scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a "brain tonic".
21. Beltrame FL, Filho ER, Barros FA, Cortez DA, Cass QB, A validated higher-performance liquid chromatography
method for quantification of cinchonain Ib in bark and phytopharmaceuticals of Trichilia catigua used as Catuaba, Journal of
Chromatography, 2006,1119(1-2), 257-263;
22. Boquett Lagos J., Bruel Gemin C.A., de Fátima Gaspari Dias J., Dallarmi Miguel M., Campos R., de Souza
Carvalho J.L., do Rocio Duarte M. Gomes M.O. Contribution to the Study of Phytosterols and Phenolics from the Barks and Leaves of
the Trichilia catigua A. Juss., Meliaceae // Journal of Analytical Sciences, Methods and Instrumentation, 2012, 2, 37-41
23. Tang W., Hioki H., Harada K., Kubo M., Fukuyama Y. Antioxidant phenylpropanoid-substituted epicatechins from Trichilia catigua. // J. Nat. Prod. 2007, 70(12), рр.2010-2013.
24. Rafael C. Dutra, Maria M. Camposc, Adair R.S. Santos, João B. Calixto. Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives // Pharmacological Research 112 (2016) 4–29
25. Longhini R, Lonni AASG, Sereia AL, Krzyzaniak LM, Lopes GC, de Mello JCP. Trichilia catigua: therapeutic and
cosmetic values. Braz J Pharmacogn. 2017;27:254–71;
26. Kamdem JP, Olalekan EO, Hassan W, Kade IJ, Yetunde O, Boligon AA, Athayde ML, Souza DO, Rocha JBT. Trichilia
catigua (Catuaba) bark extract exerts neuroprotection against oxidative stress induced by different neurotoxic agents in rat hippocampal
slices. Ind Crop Prod. 2013;50:625–32;
27. Chassot JM, Longhini R, Gazarini L, Mello JCP, De Oliveira RMW. Preclinical evaluation of Trichilia catigua extracts on
the central nervous system of mice. J Ethnopharmacol. 2011;137:1143–8;
28. Martins NO, de Brito IM, Araujo SSO, Negri G, Carlini EA, Mendes FR (2018) Antioxidant, anticholinesterase and
antifatigue effects of Trichilia catigua (catuaba). BMC Complement Alternat Med 18:172.
29. Kletter C, Glasi S, Presser A, Werner I, Reznicek G etal, Morphological, chemical and functional analysis of catuaba
preparations, Planta Medica, 2004, 70(10), 993-1000.
30. Mendes FR, Carlini EA, Brazilian plants as possible adaptogens: an ethnopharmacological survey of books edited in
Brazil, Journal of Ethnopharmacology, 2007, 109(3), 493-500;
31. Chassot JM, Longhini R, Gazarini L, Mello JC, de Oliveira RM, Preclinical evaluation of Trichilia catigua extracts on the central nervous system of mice, Journal of Ethnopharmacology, 2011, 137(3), 1143-1148.
32. Viana AF, Maciel IS, Motta EM, Leal PC, Pianowski L, Campos MM, Calixto JB. Antinociceptive activity of Trichilia catigua hydroalcoholic extract: new evidence on its dopaminergic effects. Evidence-based Complement Altern Med. 2011;
33. Truiti M.T., Soares L., Longhini R., Milani H., Nakamura C.V., Mello J.C., de Oliveira R.M. Trichilia catigua ethyl-acetate
fraction protects against cognitive impairments and hippocampal cell death induced by bilateral common carotid occlusion in mice. // J.
Ethnopharmacol. 2015, 172, рр.232-237;
34. Campos MM, Fernandes ES, Ferreira J, Santos ARS, Calixto JB. Antidepressant-like effects of Trichilia catigua
(Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology (Berl). 2005;182:45–53.
35. Viana AF, Maciel IS, Motta EM, Leal PC, Pianowski L, Campos MM, Calixto JB. Antinociceptive activity of Trichilia catigua hydroalcoholic extract: new evidence on its dopaminergic effects. Evidence-based Complement Altern Med. 2011
36. Patent Publication Number WO/1999/002172. Publication Date21.01.1999. PHARMACEUTICAL FORMULATIONS
COMPRISING VEGETAL MATERIAL SELECTED FROM TRICHILIA.
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO1999002172&tab=PCTDESCRIPTION
37. Патентные описания к заявкам WO2007016756A1 https://patents.google.com/patent/WO2007016756A1/en и DE10140320A1 https://patents.google.com/patent/DE10140320A1/en
38. Oliveira C.H., Moraes M.E., Moraes M.O., Bezerra F.A., Abib E., De Nucci G. Clinical toxicology study of an herbal
medicinal extract of Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides and Zingiber officinale (Catuama) in healthy volunteers.
// Phytother. Res. 2005, 19(1), рр.54-57.
39. Calixto, J.B., Cabrini, D.A., 1997. Herbal medicine Catuama induces endothelium-dependent and -independent vasorelaxant action on isolated vessels from rats,guinea-pigs and rabbits. Phytother. Res. 11, 32–38.
40. Ахвледиани, Н.Д. Эректильная дисфункция: современное состояние проблемы / Н. Д. Ахвледиани, С. Н. Алленов и др. // Медицинский совет. – 2015. – Вып. 2. – С. 28–32.
41. E. Antunes, W.M. Gordo, J.F. Oliveira, C.E. Teixeira, S. Hyslop, G. NucciThe relaxation of isolated rabbit corpus
cavernosum by the herbal medicine Catuama® and its constituents. Phytother. Res., 15 (2001), pp. 416-421
42. Longhini R, Lonni AASG, Sereia AL, Krzyzaniak LM, Lopes GC, de Mello JCP. Trichilia catigua: therapeutic and
cosmetic values. Braz J Pharmacogn. 2017;27:254–71
- Directions for use:Adults take 2 capsules 3 times a day at the beginning of a meal. Course duration: 20 days; the course may be repeated if necessary
- Dosage form:capsules with liquid plant extracts, 830 mg
- Pack size:120 capsules
- Directions for use:Adults take 2 capsules 3 times a day at the beginning of a meal. Course duration: 20 days; the course may be repeated if necessary
- Dosage form:capsules with liquid plant extracts, 830 mg
- Pack size:120 capsules
Taking 6 capsules provides:
Taking 6 capsules provides:
* AI — adequate intake level according to the “Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)”, Appendix 5.
Contraindications: individual intolerance to components. Consult a physician before use.
State registration certificate: No. RU.77.99.11.003.R.004967.12.21 dated 27.12.2021 – open document
Contraindications: individual intolerance to components. Consult a physician before use.
State registration certificate: No. RU.77.99.11.003.R.004967.12.21 dated 27.12.2021 – open document
* AI — adequate intake level according to the “Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)”, Appendix 5.
Contraindications: individual intolerance to components. Consult a physician before use.
State registration certificate: No. RU.77.99.11.003.R.004967.12.21 dated 27.12.2021 – open document
Contraindications: individual intolerance to components. Consult a physician before use.
State registration certificate: No. RU.77.99.11.003.R.004967.12.21 dated 27.12.2021 – open document
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