Immuno planta
IMMUNO PLANTA® is a complex of three wild Amazonian plants—Uña de Gato (Uncaria tomentosa), Lapacho (Tabebuia avellanedae), and Chuchuhuasi (Maytenus macrocarpa)—designed to strengthen the body and help counter inflammatory processes. These medicinal plants stimulate the immune system, increase the body’s resistance to viral and infectious diseases, support the musculoskeletal system, and have oncoprotective properties.
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Uña de gato / Cat's Claw (Uncaria tomentosa)
Chuchuhuasi (Maytenus macrocarpa)
Lapacho /Pau d’arco (Tabebuia avellanedae)
Uña de gato literally translates as "cat's claw". It is a woody vine of the Rubiaceae family that grows in the tropical forests of South and Central America. The plant got its name from sharp, curved thorns that help it climb around trees and look very much like a cat’s claws.
Two species are commonly known as "cat's claw": Uncaria tomentosa and Uncaria guianensis. Both are used in medicine mainly for their anti-inflammatory and immune-stimulating properties. The Shipibo people we work with consider Uncaria tomentosa more effective, so this is the species we use in IMMUNO PLANTA®.
Ethnopharmacological reports indicate a long tradition of using Uña de gato by indigenous peoples of South America to treat asthma, various acute and chronic inflammatory conditions, arthritis, rheumatism, breast cancer, allergies, inflammations of the genitourinary system, and more.
Both in vitro and in vivo studies confirm the plant’s very broad range of therapeutic properties. The active compounds of Uña de gato suppress inflammatory processes, stimulate and strengthen immunity, help counter the spread of tumor cells, and show antibacterial activity against Streptococcus mutans and Staphylococcus spp. Uña de gato extracts are taken as a standalone remedy or as part of combination therapy for the prevention of colds, infectious and inflammatory diseases, and also as an adjuvant in the treatment of certain cancers—supporting recovery after chemotherapy and activating the body’s regenerative processes.
Two species are commonly known as "cat's claw": Uncaria tomentosa and Uncaria guianensis. Both are used in medicine mainly for their anti-inflammatory and immune-stimulating properties. The Shipibo people we work with consider Uncaria tomentosa more effective, so this is the species we use in IMMUNO PLANTA®.
Ethnopharmacological reports indicate a long tradition of using Uña de gato by indigenous peoples of South America to treat asthma, various acute and chronic inflammatory conditions, arthritis, rheumatism, breast cancer, allergies, inflammations of the genitourinary system, and more.
Both in vitro and in vivo studies confirm the plant’s very broad range of therapeutic properties. The active compounds of Uña de gato suppress inflammatory processes, stimulate and strengthen immunity, help counter the spread of tumor cells, and show antibacterial activity against Streptococcus mutans and Staphylococcus spp. Uña de gato extracts are taken as a standalone remedy or as part of combination therapy for the prevention of colds, infectious and inflammatory diseases, and also as an adjuvant in the treatment of certain cancers—supporting recovery after chemotherapy and activating the body’s regenerative processes.
The most important group of active substances in this plant’s chemical profile is its numerous alkaloids (basic nitrogen-containing compounds), which are present in Uña de gato in unusually high amounts compared to many other plants, including other species of the Uncaria genus. The best studied are tetracyclic oxindole alkaloids such as corynoxeine, isocorynoxeine, rhynchophylline, and isorhynchophylline, which act on the central nervous system, and pentacyclic oxindole alkaloids including mitraphylline, isomitraphylline, pteropodine, isopteropodine, speciophylline, and uncarine F, which act on the immune system.
The compounds responsible for the anti-inflammatory activity of Uña de gato extracts are still debated: some researchers attribute this effect to pentacyclic oxindole alkaloids, while others link it to phenolic compounds such as chlorogenic and quinic acids. It has also been noted that the anti-inflammatory effect is reduced when isolated active components are used, compared with a full-spectrum extract. Most likely, the biological activity of Uña de gato is enhanced by the combined action of all its compounds, working synergistically. Therefore, it is preferable to use a full extract rather than isolated components.
Another important point is that the concentration of active compounds depends on the season and geographic location. This is why Uña de gato is harvested in the right place and at the right time; growing it for pharmaceutical purposes outside certain regions of South America makes little sense.
The compounds responsible for the anti-inflammatory activity of Uña de gato extracts are still debated: some researchers attribute this effect to pentacyclic oxindole alkaloids, while others link it to phenolic compounds such as chlorogenic and quinic acids. It has also been noted that the anti-inflammatory effect is reduced when isolated active components are used, compared with a full-spectrum extract. Most likely, the biological activity of Uña de gato is enhanced by the combined action of all its compounds, working synergistically. Therefore, it is preferable to use a full extract rather than isolated components.
Another important point is that the concentration of active compounds depends on the season and geographic location. This is why Uña de gato is harvested in the right place and at the right time; growing it for pharmaceutical purposes outside certain regions of South America makes little sense.
Chuchuhuasi—Maytenus macrocarpa (Maytenus macrocarpa)—belongs to the Celastraceae family. Common names include Chuchuhuasi (Chuchuhuasi), Chuchuwasha (Chuchuwasha), and Chuchuasi (Chuchuasi). Maytenus macrocarpa is a large evergreen tree up to 30 m tall, with reddish-brown bark and whorled branches. It grows mainly in lowland tropical forests in Peru, Bolivia, Brazil, Colombia, and Ecuador.
Chuchuhuasi bark has been used for medicinal purposes in the tribal medicine of Bolivia, Colombia, Ecuador, and Peru for many centuries. Its Peruvian name, Chuchuhuasi, means “trembling back”, which is linked to its long-standing use for arthritis, rheumatism, and back pain. Chuchuhuasi is also used to treat asthma, colds, cough, bronchitis, and influenza; as an antipyretic and analgesic; for the treatment of malaria; as a stimulant when libido is reduced; and as a general tonic.
For example, local Amazon residents infuse Chuchuhuasi bark in local sugarcane rum and use it as a botanical “doping” drink (often called “juice for running”) to relieve muscle pain and increase endurance during long treks through the Amazon selva.
Maytenus macrocarpa contains: ebenifoline alkaloids, sesquiterpenoids, flavonoids, sterols, canophyllol, catechin tannins, dammarane triterpenes, dulcitol, friedelane triterpenes, phenols, macrocarpine triterpenes, maytansine, mebeverine, maytenin, pristimerin, proanthocyanidins, and tingenone (and its derivatives).
For example, local Amazon residents infuse Chuchuhuasi bark in local sugarcane rum and use it as a botanical “doping” drink (often called “juice for running”) to relieve muscle pain and increase endurance during long treks through the Amazon selva.
Maytenus macrocarpa contains: ebenifoline alkaloids, sesquiterpenoids, flavonoids, sterols, canophyllol, catechin tannins, dammarane triterpenes, dulcitol, friedelane triterpenes, phenols, macrocarpine triterpenes, maytansine, mebeverine, maytenin, pristimerin, proanthocyanidins, and tingenone (and its derivatives).
Lapacho, also known as the "ant tree" or Pau d’arco, is a huge, beautifully flowering tree that grows in the tropical forests of the Amazon and in the cerrado of South America.
It is one of the two strongest South American trees: indigenous people make dugout canoes, oars, bows, and agricultural tools from it. However, its most valuable feature is its medicinal qualities. The medicinal raw material is the bark. It is difficult to separate from the wood, so it is harvested during sap flow—when the bark is richest in beneficial substances.
Long before this remarkable tree gained worldwide popularity, indigenous tribes of South America used a decoction of Lapacho bark for fever, colds, various lung diseases, dysentery and other gastrointestinal disorders, urinary tract infections, arthritis, and as an immunomodulatory remedy. Externally, the bark was used for ulcers, burns, and fungal skin lesions.
Today, Lapacho is widely used in combined immune-supporting and anti-inflammatory protocols alongside Uña de gato. The bark extract is used for gastrointestinal disorders, prostatitis, urinary tract infections (cystitis, urethritis, and pyelonephritis), for the treatment of malaria, colds, influenza and other viral respiratory infections, bronchopulmonary diseases, various fungal and yeast infections, and also in the treatment of certain cancers.
It is one of the two strongest South American trees: indigenous people make dugout canoes, oars, bows, and agricultural tools from it. However, its most valuable feature is its medicinal qualities. The medicinal raw material is the bark. It is difficult to separate from the wood, so it is harvested during sap flow—when the bark is richest in beneficial substances.
Long before this remarkable tree gained worldwide popularity, indigenous tribes of South America used a decoction of Lapacho bark for fever, colds, various lung diseases, dysentery and other gastrointestinal disorders, urinary tract infections, arthritis, and as an immunomodulatory remedy. Externally, the bark was used for ulcers, burns, and fungal skin lesions.
Today, Lapacho is widely used in combined immune-supporting and anti-inflammatory protocols alongside Uña de gato. The bark extract is used for gastrointestinal disorders, prostatitis, urinary tract infections (cystitis, urethritis, and pyelonephritis), for the treatment of malaria, colds, influenza and other viral respiratory infections, bronchopulmonary diseases, various fungal and yeast infections, and also in the treatment of certain cancers.
Lapacho’s beneficial properties are due to its complex chemical composition. Some of its main active ingredients are naphthoquinones extracted from the bark, including lapachol and its derivatives α‑lapachone and β‑lapachone, as well as a more recently discovered quinone called "xyloidone". Other compounds identified include lapachenol, quercetin, and o‑ and p‑hydroxybenzoic acids.
Studies have found that lapachol has both antimicrobial and antiviral activity; β‑lapachone shows antiviral activity; α‑lapachone is active against parasites; and xyloidone is active against many bacteria and fungi.
Modern scientific research confirms the effects of lapachol and its derivatives on tumor cells (including pancreatic, lung, breast, and prostate cancers), as well as the potential of certain isolated naphthoquinones from Lapacho bark as preventive anti-tumor agents and as compounds that may help improve clinical outcomes in patients with tumor diseases.
Another Lapacho component—the flavonoid quercetin—is cytotoxic to certain parasites. Xyloidone is effective against a wide range of organisms, including Staphylococcus aureus and Brucella species. This compound also suppresses the pathogens that cause tuberculosis, dysentery, and anthrax. The activity of lapachol, α‑lapachone, β‑lapachone, and xyloidone against E. coli—the main causative agent of infectious cystitis and prostatitis—supports the traditional use of Lapacho for the treatment and prevention of genitourinary diseases of fungal and bacterial origin.
Studies have found that lapachol has both antimicrobial and antiviral activity; β‑lapachone shows antiviral activity; α‑lapachone is active against parasites; and xyloidone is active against many bacteria and fungi.
Modern scientific research confirms the effects of lapachol and its derivatives on tumor cells (including pancreatic, lung, breast, and prostate cancers), as well as the potential of certain isolated naphthoquinones from Lapacho bark as preventive anti-tumor agents and as compounds that may help improve clinical outcomes in patients with tumor diseases.
Another Lapacho component—the flavonoid quercetin—is cytotoxic to certain parasites. Xyloidone is effective against a wide range of organisms, including Staphylococcus aureus and Brucella species. This compound also suppresses the pathogens that cause tuberculosis, dysentery, and anthrax. The activity of lapachol, α‑lapachone, β‑lapachone, and xyloidone against E. coli—the main causative agent of infectious cystitis and prostatitis—supports the traditional use of Lapacho for the treatment and prevention of genitourinary diseases of fungal and bacterial origin.
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de Loreto y chamanes de Lima (Perú) // Revista de Fitoterapia 2013; 13 (1): 61-69
62. Santoyo C. Z., Espinoza L. Z., Puente R. Z., Sánchez J. Z., Quispe N. Z., Medina C. P. and
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macrocarpa (Ruiz &Pav.) Briq.in mice // Pharmacognosy Communications, 2015; 5, (4),: 244-249
63. Torpocco V., Chávez H., Estévez-Braun A., Ravelo Á. G. New Dammarane Triterpenes from
Maytenus macrocarpa. // Chem. Pharm. Bull. 2007; 55(5): 812—814
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Castañeda B. Comparación de los usos del chuchuhuasi (Maytenus macrocarpa) entre indígenas Bora-Bora
de Loreto y chamanes de Lima (Perú) // Revista de Fitoterapia 2013; 13 (1): 61-69
62. Santoyo C. Z., Espinoza L. Z., Puente R. Z., Sánchez J. Z., Quispe N. Z., Medina C. P. and
Granara A. S. Antipsychotic and behavior effect of the ethanolic extract from the bark of Maytenus
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63. Torpocco V., Chávez H., Estévez-Braun A., Ravelo Á. G. New Dammarane Triterpenes from
Maytenus macrocarpa. // Chem. Pharm. Bull. 2007; 55(5): 812—814
- Directions for use:Adults take 2 capsules 3 times a day at the beginning of a meal. Course duration: 20 days; the course may be repeated if necessary.
- Dosage form:capsules with liquid plant extracts, 830 mg.
- Pack size:20 capsules.
Taking 6 capsules provides:
* RDI — recommended daily intake level according to CU TR 022/2011, Appendix 2.
AI — adequate intake level according to the “Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)”, Appendix 5.
** Does not exceed the tolerable upper intake level according to Appendix 5 of the above Unified sanitary-epidemiological and hygienic requirements of the EAEU Customs Union.
Contraindications: individual intolerance to components. Consult a physician before use.
State Registration Certificate: No. RU.77.99.11.003.R.004962.12.21 dated 27.12.2021 – open document
AI — adequate intake level according to the “Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)”, Appendix 5.
** Does not exceed the tolerable upper intake level according to Appendix 5 of the above Unified sanitary-epidemiological and hygienic requirements of the EAEU Customs Union.
Contraindications: individual intolerance to components. Consult a physician before use.
State Registration Certificate: No. RU.77.99.11.003.R.004962.12.21 dated 27.12.2021 – open document
Uña de gato / Cat's Claw (Uncaria tomentosa)
Chuchuhuasi (Maytenus macrocarpa)
Lapacho /Pau d’arco (Tabebuia avellanedae)
Uña de gato literally translates as "cat's claw". It is a woody vine of the Rubiaceae family that grows in the tropical forests of South and Central America. The plant got its name from sharp, curved thorns that help it climb around trees and look very much like a cat’s claws.
Two species are commonly known as "cat's claw": Uncaria tomentosa and Uncaria guianensis. Both are used in medicine mainly for their anti-inflammatory and immune-stimulating properties. The Shipibo people we work with consider Uncaria tomentosa more effective, so this is the species we use in IMMUNO PLANTA®.
Ethnopharmacological reports indicate a long tradition of using Uña de gato by indigenous peoples of South America to treat asthma, various acute and chronic inflammatory conditions, arthritis, rheumatism, breast cancer, allergies, inflammations of the genitourinary system, and more.
Both in vitro and in vivo studies confirm the plant’s very broad range of therapeutic properties. The active compounds of Uña de gato suppress inflammatory processes, stimulate and strengthen immunity, help counter the spread of tumor cells, and show antibacterial activity against Streptococcus mutans and Staphylococcus spp. Uña de gato extracts are taken as a standalone remedy or as part of combination therapy for the prevention of colds, infectious and inflammatory diseases, and also as an adjuvant in the treatment of certain cancers—supporting recovery after chemotherapy and activating the body’s regenerative processes.
Two species are commonly known as "cat's claw": Uncaria tomentosa and Uncaria guianensis. Both are used in medicine mainly for their anti-inflammatory and immune-stimulating properties. The Shipibo people we work with consider Uncaria tomentosa more effective, so this is the species we use in IMMUNO PLANTA®.
Ethnopharmacological reports indicate a long tradition of using Uña de gato by indigenous peoples of South America to treat asthma, various acute and chronic inflammatory conditions, arthritis, rheumatism, breast cancer, allergies, inflammations of the genitourinary system, and more.
Both in vitro and in vivo studies confirm the plant’s very broad range of therapeutic properties. The active compounds of Uña de gato suppress inflammatory processes, stimulate and strengthen immunity, help counter the spread of tumor cells, and show antibacterial activity against Streptococcus mutans and Staphylococcus spp. Uña de gato extracts are taken as a standalone remedy or as part of combination therapy for the prevention of colds, infectious and inflammatory diseases, and also as an adjuvant in the treatment of certain cancers—supporting recovery after chemotherapy and activating the body’s regenerative processes.
The most important group of active substances in this plant’s chemical profile is its numerous alkaloids (basic nitrogen-containing compounds), which are present in Uña de gato in unusually high amounts compared to many other plants, including other species of the Uncaria genus. The best studied are tetracyclic oxindole alkaloids such as corynoxeine, isocorynoxeine, rhynchophylline, and isorhynchophylline, which act on the central nervous system, and pentacyclic oxindole alkaloids including mitraphylline, isomitraphylline, pteropodine, isopteropodine, speciophylline, and uncarine F, which act on the immune system.
The compounds responsible for the anti-inflammatory activity of Uña de gato extracts are still debated: some researchers attribute this effect to pentacyclic oxindole alkaloids, while others link it to phenolic compounds such as chlorogenic and quinic acids. It has also been noted that the anti-inflammatory effect is reduced when isolated active components are used, compared with a full-spectrum extract. Most likely, the biological activity of Uña de gato is enhanced by the combined action of all its compounds, working synergistically. Therefore, it is preferable to use a full extract rather than isolated components.
Another important point is that the concentration of active compounds depends on the season and geographic location. This is why Uña de gato is harvested in the right place and at the right time; growing it for pharmaceutical purposes outside certain regions of South America makes little sense.
The compounds responsible for the anti-inflammatory activity of Uña de gato extracts are still debated: some researchers attribute this effect to pentacyclic oxindole alkaloids, while others link it to phenolic compounds such as chlorogenic and quinic acids. It has also been noted that the anti-inflammatory effect is reduced when isolated active components are used, compared with a full-spectrum extract. Most likely, the biological activity of Uña de gato is enhanced by the combined action of all its compounds, working synergistically. Therefore, it is preferable to use a full extract rather than isolated components.
Another important point is that the concentration of active compounds depends on the season and geographic location. This is why Uña de gato is harvested in the right place and at the right time; growing it for pharmaceutical purposes outside certain regions of South America makes little sense.
Chuchuhuasi—Maytenus macrocarpa (Maytenus macrocarpa)—belongs to the Celastraceae family. Common names include Chuchuhuasi (Chuchuhuasi), Chuchuwasha (Chuchuwasha), and Chuchuasi (Chuchuasi). Maytenus macrocarpa is a large evergreen tree up to 30 m tall, with reddish-brown bark and whorled branches. It grows mainly in lowland tropical forests in Peru, Bolivia, Brazil, Colombia, and Ecuador.
Chuchuhuasi bark has been used for medicinal purposes in the tribal medicine of Bolivia, Colombia, Ecuador, and Peru for many centuries. Its Peruvian name, Chuchuhuasi, means “trembling back”, which is linked to its long-standing use for arthritis, rheumatism, and back pain. Chuchuhuasi is also used to treat asthma, colds, cough, bronchitis, and influenza; as an antipyretic and analgesic; for the treatment of malaria; as a stimulant when libido is reduced; and as a general tonic.
For example, local Amazon residents infuse Chuchuhuasi bark in local sugarcane rum and use it as a botanical “doping” drink (often called “juice for running”) to relieve muscle pain and increase endurance during long treks through the Amazon selva.
Maytenus macrocarpa contains: ebenifoline alkaloids, sesquiterpenoids, flavonoids, sterols, canophyllol, catechin tannins, dammarane triterpenes, dulcitol, friedelane triterpenes, phenols, macrocarpine triterpenes, maytansine, mebeverine, maytenin, pristimerin, proanthocyanidins, and tingenone (and its derivatives).
For example, local Amazon residents infuse Chuchuhuasi bark in local sugarcane rum and use it as a botanical “doping” drink (often called “juice for running”) to relieve muscle pain and increase endurance during long treks through the Amazon selva.
Maytenus macrocarpa contains: ebenifoline alkaloids, sesquiterpenoids, flavonoids, sterols, canophyllol, catechin tannins, dammarane triterpenes, dulcitol, friedelane triterpenes, phenols, macrocarpine triterpenes, maytansine, mebeverine, maytenin, pristimerin, proanthocyanidins, and tingenone (and its derivatives).
Lapacho, also known as the "ant tree" or Pau d’arco, is a huge, beautifully flowering tree that grows in the tropical forests of the Amazon and in the cerrado of South America.
It is one of the two strongest South American trees: indigenous people make dugout canoes, oars, bows, and agricultural tools from it. However, its most valuable feature is its medicinal qualities. The medicinal raw material is the bark. It is difficult to separate from the wood, so it is harvested during sap flow—when the bark is richest in beneficial substances.
Long before this remarkable tree gained worldwide popularity, indigenous tribes of South America used a decoction of Lapacho bark for fever, colds, various lung diseases, dysentery and other gastrointestinal disorders, urinary tract infections, arthritis, and as an immunomodulatory remedy. Externally, the bark was used for ulcers, burns, and fungal skin lesions.
Today, Lapacho is widely used in combined immune-supporting and anti-inflammatory protocols alongside Uña de gato. The bark extract is used for gastrointestinal disorders, prostatitis, urinary tract infections (cystitis, urethritis, and pyelonephritis), for the treatment of malaria, colds, influenza and other viral respiratory infections, bronchopulmonary diseases, various fungal and yeast infections, and also in the treatment of certain cancers.
It is one of the two strongest South American trees: indigenous people make dugout canoes, oars, bows, and agricultural tools from it. However, its most valuable feature is its medicinal qualities. The medicinal raw material is the bark. It is difficult to separate from the wood, so it is harvested during sap flow—when the bark is richest in beneficial substances.
Long before this remarkable tree gained worldwide popularity, indigenous tribes of South America used a decoction of Lapacho bark for fever, colds, various lung diseases, dysentery and other gastrointestinal disorders, urinary tract infections, arthritis, and as an immunomodulatory remedy. Externally, the bark was used for ulcers, burns, and fungal skin lesions.
Today, Lapacho is widely used in combined immune-supporting and anti-inflammatory protocols alongside Uña de gato. The bark extract is used for gastrointestinal disorders, prostatitis, urinary tract infections (cystitis, urethritis, and pyelonephritis), for the treatment of malaria, colds, influenza and other viral respiratory infections, bronchopulmonary diseases, various fungal and yeast infections, and also in the treatment of certain cancers.
Lapacho’s beneficial properties are due to its complex chemical composition. Some of its main active ingredients are naphthoquinones extracted from the bark, including lapachol and its derivatives α‑lapachone and β‑lapachone, as well as a more recently discovered quinone called "xyloidone". Other compounds identified include lapachenol, quercetin, and o‑ and p‑hydroxybenzoic acids.
Studies have found that lapachol has both antimicrobial and antiviral activity; β‑lapachone shows antiviral activity; α‑lapachone is active against parasites; and xyloidone is active against many bacteria and fungi.
Modern scientific research confirms the effects of lapachol and its derivatives on tumor cells (including pancreatic, lung, breast, and prostate cancers), as well as the potential of certain isolated naphthoquinones from Lapacho bark as preventive anti-tumor agents and as compounds that may help improve clinical outcomes in patients with tumor diseases.
Another Lapacho component—the flavonoid quercetin—is cytotoxic to certain parasites. Xyloidone is effective against a wide range of organisms, including Staphylococcus aureus and Brucella species. This compound also suppresses the pathogens that cause tuberculosis, dysentery, and anthrax. The activity of lapachol, α‑lapachone, β‑lapachone, and xyloidone against E. coli—the main causative agent of infectious cystitis and prostatitis—supports the traditional use of Lapacho for the treatment and prevention of genitourinary diseases of fungal and bacterial origin.
Studies have found that lapachol has both antimicrobial and antiviral activity; β‑lapachone shows antiviral activity; α‑lapachone is active against parasites; and xyloidone is active against many bacteria and fungi.
Modern scientific research confirms the effects of lapachol and its derivatives on tumor cells (including pancreatic, lung, breast, and prostate cancers), as well as the potential of certain isolated naphthoquinones from Lapacho bark as preventive anti-tumor agents and as compounds that may help improve clinical outcomes in patients with tumor diseases.
Another Lapacho component—the flavonoid quercetin—is cytotoxic to certain parasites. Xyloidone is effective against a wide range of organisms, including Staphylococcus aureus and Brucella species. This compound also suppresses the pathogens that cause tuberculosis, dysentery, and anthrax. The activity of lapachol, α‑lapachone, β‑lapachone, and xyloidone against E. coli—the main causative agent of infectious cystitis and prostatitis—supports the traditional use of Lapacho for the treatment and prevention of genitourinary diseases of fungal and bacterial origin.
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toxicity of C-MED-100(TM), a novel aqueous extract from Uncaria tomentosa. //Journal of
Ethnopharmacology. 2000;69(2):115–126
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ethnopharmacological commodity? J Ethnopharmacol. 2009 Jan 12;121(1):1-13. doi:
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Elsevier Health Sciences. p. 868-872.
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research(1997-2016). Expert Opin Ther Pat. 2017 Oct;27(10):1111-1121. doi:
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5. Hardin, S. R. Cat's claw: an Amazonian vine decreases inflammation in
osteoarthritis. Complement Ther Clin Pract 2007;13(1):25-28.
6. Sandoval, M., Okuhama, N. N., Zhang, X. J., Condezo, L. A., Lao, J., Angeles', F. M.,
Musah, R. A., Bobrowski, P., and Miller, M. J. Anti-inflammatory and antioxidant activities of cat's claw
(Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid
content. Phytomedicine 2002;9(4):325-337
7. Senatore, A., Cataldo, A., Iaccarino, F. P., and Elberti, M. G. [Phytochemical and biological
study of Uncaria tomentosa]. Boll Soc Ital Biol Sper 1989;65(6):517-520
8. Gonçalves C, Dinis T, Batista MT. Antioxidant properties of proanthocyanidins of Uncaria
tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry. 2005 Jan;66(1):89-
98. doi: 10.1016/j.phytochem.2004.10.025. PMID: 15649515.
9. Miller, M. J., Mehta, K., Kunte, S., Raut, V., Gala, J., Dhumale, R., Shukla, A., Tupalli, H.,
Parikh, H., Bobrowski, P., and Chaudhary, J. Early relief of osteoarthritis symptoms with a natural mineral
supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. J Inflamm
(Lond) 10-21-2005;2:11.
10. Barnes J., Anderson L.A., Phillipson J.D. Herbal medcines. London - Pharmaceutical Press.
- third edition. 2007. 721 p.
11. Jalloh M.A., Gregory PJ, Hein D., R.Cochrane Z, Rodrigues A .Dietary supplement
interactions with antiretrovirals: a systematic review.// Int J STD AIDS 2017 Jan;28(1):4-15.
12. Akhtar N., Haqqi T.M. Current nutraceuticals in the management of osteoarthritis: a review //
Ther Adv Musculoskelet Dis. 2012 Jun;4(3):181-207
13. de Paula L.C., Fonseca F., Perazzo F. , Cruz FM, Cubero D, Trufeli DC, Martins SP, Santi
PX, da Silva EA, Del Giglio A. Uncaria tomentosa (cat's claw) improves quality of life in patients with
advanced solid tumors. /J Altern Complement Med. 2015 Jan;21(1):22-30
14. Santos A.Mdo C, Farias IL, Gutierres J, Dalmora SL, Flores N, Farias J, de Cruz I, Chiesa J,
Morscj VM, Chitolina Schetinger MR. Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical
Trial.// Evid Based Complement Alternat Med. 2012;2012:676984.
15. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced
toxicity of C-MED-100(TM), a novel aqueous extract from Uncaria tomentosa. //Journal of
Ethnopharmacology. 2000;69(2):115–126
16. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global
ethnopharmacological commodity? J Ethnopharmacol. 2009 Jan 12;121(1):1-13. doi:
10.1016/j.jep.2008.10.004. Epub 2008 Nov 1. PMID: 18992801.
17. Kuštrak, D. Taheebo-Lapacho-Tabebuia impetiginosa (syn. Tabebuia avellanedae)//
Farmaceutski Glasnik, Jan. 2001, 56 (6), p. 215-222
18. Bussmann R.W. (2018) Tabebuia avellanedae Lorentz ex Griseb.. In: Albuquerque U., Patil U.,
Máthé Á. (eds) Medicinal and Aromatic Plants of South America. Medicinal and Aromatic Plants of the World,
vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1552-0_40
19. Burnett AR, Thomson RH (1967b) Naturally occurring quinones. Part X. The quinonoid
constituents of Tabebuia avellanedae (Bignoniaceae). J Chem Soc (C): 2100-2104
20. Joseph E. Pizzorno, Michael T. Murray (2020). Textbook of Natural Medicine - E-Book, vol.5,
Elsevier Health Sciences. p. 868-872.
21. Hussain H, Green IR. Lapachol and lapachone analogs: a journey of two decades of patent
research(1997-2016). Expert Opin Ther Pat. 2017 Oct;27(10):1111-1121. doi:
10.1080/13543776.2017.1339792. Epub 2017 Jun 14. Erratum in: Expert Opin Ther Pat. 2017 Oct;27(10
):1173. PMID: 28586252
22. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 470-1
23. Bernardes A: A pocket book of Brazilian herbs: folklore, history, uses. Brazil, 1983, Shogun
Arte.
24. Lima, O.G.; D.Albuquerque, I. L., Gonçalves de Lima, C., Machado, M. P. Primeiras
Observações sobre a Ação Antimicrobiana do Lapachol.- Anaisda Sociedade de Biologia de Pernambuco
14, Nº 1/2, 129-135,1956.
25. Souza MA, Johann S, Lima LA, et al. The antimicrobial activity of lapachol and its
thiosemicarbazone and semicarbazone derivatives. Mem Inst Oswaldo Cruz. 2013;108(3):342-351.
doi:10.1590/S0074-02762013000300013
26. Machado TB, Pinto AV, Pinto MC, Leal IC, Silva MG, Amaral AC, Kuster RM, Netto-dosSantos
KR (2003) In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their
analogues, against methicillin-resistant Staphylococcus aureus. International Journal of Antimicrobial
Agents 21(3):279-284 doi: 10.1016/S0924-8579(02)00349-7
27. Yamashita M, Kaneko M, Tokuda H, Nishimura K, Kumeda Y, Iida A (2009) Synthesis and
evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae.
Bioorganic & Medicinal Chemistry 17(17):6286-6291 doi: 10.1016/j.bmc.2009.07.039.
28. Pereira EM, Machado Tde B, Leal IC, Jesus DM, Damaso CR, Pinto AV, Giambiagi-deMarval M,
Kuster RM, Santos KR (2006) Tabebuia avellanedae naphthoquinones: activity against methicillin-
resistant Staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis. Annals of Clinical
Microbiology and Antimicrobials 5:5 doi: 10.1186/1476-0711-5-5.
29. Guiraud P, Steiman R, Campos-Takaki GM, Seigle-Murandi F, Simeon de Buochberg M.
Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone. Planta Medica. 1994
Aug;60(4):373-374. DOI: 10.1055/s-2006-959504.
30. Twardowschy A, Freitas CS, Baggio CH, Mayer B, dos Santos AC, Pizzolatti MG, Zacarias AA,
dos Santos EP, Otuki MF, Marques MC (2008) Antiulcerogemc activity of bark extract of Tabebuia
avellanedae, Lorentz ex Griseb. Journal of Ethnopharmacology 118(3):455-459 doi:
10.1016/j.jep.2008.05.013.
31. Portillo A, Vila R, Freixa B, Adzet T, Canigueral S (2001) Antifungal activity of Paraguayan
plants used in traditional medicine. Journal of Ethnopharmacology 76(1):93-98.
32. Hofling JF, Anibal PC, Obando-Pereda GA, Peixoto IA, Furletti VF, Foglio MA, Goncalves RB
(2010) Antimicrobial potential of some plant extracts against Candida species. Brazilian Journal of
Biology 70(4):1065-1068 doi: 10.1590/S1519-69842010000500022.
33. Kreher B, Lotter H, Cordell GA, Wagner H. New Furanonaphthoquinones and other
Constituents of Tabebuia avellanedae and their Immunomodulating Activities in vitro. Planta Med. 1988
Dec;54(6):562-3. doi: 10.1055/s-2006-962561. PMID: 17265346
34. Kenneth Jones. Pau D'Arco: Immune Power from the Rain Forest. Inner Traditions / Bear & Co,
1995
35. Byeon SE, Chung JY, Lee YG, Kim BH, Kim KH, Cho JY (2008) In vitro and in vivo anti-
inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae. J
Ethnopharmacol 119(1):145–152
36. Ma S, Yada K, Lee H, Fukuda Y, Iida A, Suzuki K. Taheebo Polyphenols Attenuate Free Fatty
Acid-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of Cyclooxygenase-2.
Front Nutr. 2017 Dec 12;4:63. doi: 10.3389/fnut.2017.00063. Erratum in: Front Nutr. 2018 Jan 30;5:2. PMID:
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- Directions for use:Adults take 2 capsules 3 times a day at the beginning of a meal. Course duration: 20 days; the course may be repeated if necessary.
- Dosage form:capsules with liquid plant extracts, 830 mg.
- Pack size:20 capsules.
Taking 6 capsules provides:
* RDI — recommended daily intake level according to CU TR 022/2011, Appendix 2.
AI — adequate intake level according to the “Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)”, Appendix 5.
** Does not exceed the tolerable upper intake level according to Appendix 5 of the above Unified sanitary-epidemiological and hygienic requirements of the EAEU Customs Union.
Contraindications: individual intolerance to components. Consult a physician before use.
State Registration Certificate: No. RU.77.99.11.003.R.004962.12.21 dated 27.12.2021 – open document
AI — adequate intake level according to the “Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)”, Appendix 5.
** Does not exceed the tolerable upper intake level according to Appendix 5 of the above Unified sanitary-epidemiological and hygienic requirements of the EAEU Customs Union.
Contraindications: individual intolerance to components. Consult a physician before use.
State Registration Certificate: No. RU.77.99.11.003.R.004962.12.21 dated 27.12.2021 – open document
