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Uña de gato / Cat's Claw（猫爪藤，Uncaria tomentosa）
Chuchuhuasi（丘丘瓦西，Maytenus macrocarpa）
Lapacho / Pau d’arco（拉帕乔/帕乌达尔科，Tabebuia avellanedae）
Uña de gato（乌尼亚·德·加托，直译“猫爪”）为茜草科（Rubiaceae）木质藤本植物，生长于中美洲与南美洲的热带雨林。其名称源自茎上尖锐弯曲的刺，能够帮助其攀附树木，外形酷似猫爪。
在“猫爪藤”这一通用名称下，常指两种植物：Uncaria tomentosa 与 Uncaria guianensis。二者在医学应用中主要因其显著的抗炎与免疫刺激特性而被使用。我们合作的希皮博（Shipibo）部族印第安人认为 Uncaria tomentosa 更为有效，因此 IMMUNO PLANTA® 采用的正是这一种。
民族药理学报告显示，南美原住民部族长期将 Uña de gato 用于哮喘、各种急性与慢性炎症过程、关节炎、风湿、乳腺癌、过敏、泌尿生殖系统炎症等。
体外（in vitro）与体内（in vivo）研究证实，该植物具有极为广泛的生物学作用。Uña de gato 的活性成分可抑制炎症过程，激活并增强免疫力，抑制肿瘤细胞扩散，并对变形链球菌（Streptococcus mutans）与葡萄球菌属（Staphylococcus spp.）表现出抗菌活性。Uña de gato 提取物可单独使用，亦可用于综合疗法中，以预防感冒、感染性与炎症性疾病；同时还可作为肿瘤疾病治疗的辅助，用于化疗后机体恢复并促进再生过程。
在“猫爪藤”这一通用名称下，常指两种植物：Uncaria tomentosa 与 Uncaria guianensis。二者在医学应用中主要因其显著的抗炎与免疫刺激特性而被使用。我们合作的希皮博（Shipibo）部族印第安人认为 Uncaria tomentosa 更为有效，因此 IMMUNO PLANTA® 采用的正是这一种。
民族药理学报告显示，南美原住民部族长期将 Uña de gato 用于哮喘、各种急性与慢性炎症过程、关节炎、风湿、乳腺癌、过敏、泌尿生殖系统炎症等。
体外（in vitro）与体内（in vivo）研究证实，该植物具有极为广泛的生物学作用。Uña de gato 的活性成分可抑制炎症过程，激活并增强免疫力，抑制肿瘤细胞扩散，并对变形链球菌（Streptococcus mutans）与葡萄球菌属（Staphylococcus spp.）表现出抗菌活性。Uña de gato 提取物可单独使用，亦可用于综合疗法中，以预防感冒、感染性与炎症性疾病；同时还可作为肿瘤疾病治疗的辅助，用于化疗后机体恢复并促进再生过程。
该植物化学成分中最重要的一类活性物质是其多种生物碱（主要的含氮碱性化合物）。与其他植物（包括同属 Uncaria 的其他种）相比，Uña de gato 中生物碱含量异常丰富。研究最充分的包括：四环氧吲哚生物碱（如 corincoxine、isocorincoxine、rhynchophylline、isorhynchophylline），其作用于中枢神经系统；以及五环氧吲哚生物碱（包括 mitraphylline、isomitraphylline、pteropodine、isopteropodine、speciophylline、uncarine F），其作用于免疫系统。
关于 Uña de gato 提取物抗炎活性所对应的具体成分，目前仍存在争议：一些研究者将其归因于五环氧吲哚生物碱，另一些则认为与酚类化合物（如绿原酸与奎尼酸）有关。同时也观察到，相比完整提取物，使用分离得到的单一活性成分时，抗炎效应会减弱。很可能 Uña de gato 的生物活性来自其所含多种化学成分的协同作用。因此，更推荐摄入完整提取物，而非从中分离出的单一成分。
另一个重要因素是：活性成分的浓度与季节及地理位置有关，因此 Uña de gato 需要在合适的地点与时节采收。若在南美特定区域之外以药用目的进行种植，意义不大。
关于 Uña de gato 提取物抗炎活性所对应的具体成分，目前仍存在争议：一些研究者将其归因于五环氧吲哚生物碱，另一些则认为与酚类化合物（如绿原酸与奎尼酸）有关。同时也观察到，相比完整提取物，使用分离得到的单一活性成分时，抗炎效应会减弱。很可能 Uña de gato 的生物活性来自其所含多种化学成分的协同作用。因此，更推荐摄入完整提取物，而非从中分离出的单一成分。
另一个重要因素是：活性成分的浓度与季节及地理位置有关，因此 Uña de gato 需要在合适的地点与时节采收。若在南美特定区域之外以药用目的进行种植，意义不大。
Chuchuhuasi（丘丘瓦西；亦写作 Chuchuwasha、Chuchuasi 等），学名 Maytenus macrocarpa，隶属卫矛科（Celastraceae）。Maytenus macrocarpa 为大型常绿乔木，高可达 30 米，树皮呈红棕色，枝条轮生。主要分布于秘鲁、玻利维亚、巴西、哥伦比亚与厄瓜多尔的低地热带雨林。
Chuchuhuasi 的树皮在玻利维亚、哥伦比亚、厄瓜多尔与秘鲁的部族医学中已使用了数百年。其秘鲁语名称意为“颤抖的背”，与其长期用于关节炎、风湿与背痛有关。Chuchuhuasi 还用于哮喘、感冒、咳嗽、支气管炎、流感等；作为退热、镇痛；用于疟疾；也被用作性欲下降时的兴奋剂，以及一般性的强身补益。比如，亚马逊当地居民常将 Chuchuhuasi 树皮浸泡于当地甘蔗朗姆酒中，作为“植物兴奋剂”（该饮品常被称为“跑步果汁”），以缓解肌肉疼痛并在长距离穿越雨林时提高耐力。
Maytenus macrocarpa 含有：ebinifoline 类生物碱、倍半萜类、黄酮类、甾醇、canophyllol、儿茶素类鞣质、达玛烷型三萜、dulcitol、friedelane 型三萜、酚类、macrocarpin 类三萜、maytansine、mebeverine、maytenin、pristimerin、原花青素以及 tingenone（及其衍生物）等。
Maytenus macrocarpa 含有：ebinifoline 类生物碱、倍半萜类、黄酮类、甾醇、canophyllol、儿茶素类鞣质、达玛烷型三萜、dulcitol、friedelane 型三萜、酚类、macrocarpin 类三萜、maytansine、mebeverine、maytenin、pristimerin、原花青素以及 tingenone（及其衍生物）等。
Lapacho（拉帕乔），亦称“蚂蚁树”，或 Pau d’arco（帕乌达尔科），是一种高大且花色绚丽的树木，生长于亚马逊雨林及南美塞拉多（Cerrado）等热带地区。
它是南美洲木质最坚硬的两种树之一：印第安人用其制作独木舟、船桨、弓以及农业工具。然而其最珍贵之处在于药用价值。药用部位为树皮。由于树皮与木质结合紧密，通常在树液流动期采收，此时树皮中的有效成分最为丰富。
在这棵树木享誉世界之前，南美印第安部族就已长期饮用其树皮煎剂，用于退热、感冒、各种肺部疾病、痢疾及其他胃肠道疾病、泌尿道感染、关节炎，并作为免疫调节手段。外用方面，树皮还用于溃疡、烧伤以及皮肤真菌感染。
目前，Lapacho 与 Uña de gato 一样，已被广泛用于综合性的免疫支持与抗炎方案。其树皮提取物用于胃肠道疾病、前列腺炎、泌尿道感染（膀胱炎、尿道炎、肾盂肾炎）、疟疾，以及感冒、流感等病毒性呼吸道感染和支气管-肺部疾病；也用于多种真菌/酵母感染，并在部分肿瘤疾病的治疗中得到应用。
它是南美洲木质最坚硬的两种树之一：印第安人用其制作独木舟、船桨、弓以及农业工具。然而其最珍贵之处在于药用价值。药用部位为树皮。由于树皮与木质结合紧密，通常在树液流动期采收，此时树皮中的有效成分最为丰富。
在这棵树木享誉世界之前，南美印第安部族就已长期饮用其树皮煎剂，用于退热、感冒、各种肺部疾病、痢疾及其他胃肠道疾病、泌尿道感染、关节炎，并作为免疫调节手段。外用方面，树皮还用于溃疡、烧伤以及皮肤真菌感染。
目前，Lapacho 与 Uña de gato 一样，已被广泛用于综合性的免疫支持与抗炎方案。其树皮提取物用于胃肠道疾病、前列腺炎、泌尿道感染（膀胱炎、尿道炎、肾盂肾炎）、疟疾，以及感冒、流感等病毒性呼吸道感染和支气管-肺部疾病；也用于多种真菌/酵母感染，并在部分肿瘤疾病的治疗中得到应用。
Lapacho 的益处源于其复杂的化学成分。主要活性成分之一为从树皮中提取的萘醌类，其中包括 lapachol 及其衍生物 α‑lapachone、β‑lapachone，以及近年发现的名为“xyloidone”的醌类化合物。另有 lapachenol、槲皮素（quercetin），以及邻/对‑羟基苯甲酸等成分。
研究发现：lapachol 具有抗微生物与抗病毒作用；β‑lapachone 表现出抗病毒活性；α‑lapachone 对寄生虫具有活性；xyloidone 对多种细菌与真菌有效。
现代科学研究还证实了 lapachol 及其衍生物对肿瘤细胞的影响（包括胰腺癌、肺癌、乳腺癌、前列腺癌等）。同时，有研究将从 Lapacho 树皮中分离得到的单体萘醌类视为潜在的肿瘤预防候选物，并可用于改善肿瘤患者的临床状态。
Lapacho 的另一成分——黄酮类槲皮素（quercetin）——对某些寄生虫具有细胞毒性。xyloidone 对广谱微生物有效，包括金黄色葡萄球菌（Staphylococcus aureus）以及布鲁氏菌属（Brucella spp.）。该成分还可抑制结核、痢疾与炭疽的病原体。lapachol、α‑lapachone、β‑lapachone 与 xyloidone 对大肠杆菌（E. coli，感染性膀胱炎与前列腺炎的主要病原）表现出的活性，也从侧面印证了 Lapacho 在传统上用于治疗与预防具有真菌或细菌性质的泌尿生殖系统疾病。
研究发现：lapachol 具有抗微生物与抗病毒作用；β‑lapachone 表现出抗病毒活性；α‑lapachone 对寄生虫具有活性；xyloidone 对多种细菌与真菌有效。
现代科学研究还证实了 lapachol 及其衍生物对肿瘤细胞的影响（包括胰腺癌、肺癌、乳腺癌、前列腺癌等）。同时，有研究将从 Lapacho 树皮中分离得到的单体萘醌类视为潜在的肿瘤预防候选物，并可用于改善肿瘤患者的临床状态。
Lapacho 的另一成分——黄酮类槲皮素（quercetin）——对某些寄生虫具有细胞毒性。xyloidone 对广谱微生物有效，包括金黄色葡萄球菌（Staphylococcus aureus）以及布鲁氏菌属（Brucella spp.）。该成分还可抑制结核、痢疾与炭疽的病原体。lapachol、α‑lapachone、β‑lapachone 与 xyloidone 对大肠杆菌（E. coli，感染性膀胱炎与前列腺炎的主要病原）表现出的活性，也从侧面印证了 Lapacho 在传统上用于治疗与预防具有真菌或细菌性质的泌尿生殖系统疾病。
- 使用说明建议用法：男性在进餐开始时，每次 2 粒，每日 3 次。建议连续使用 20 天；如有需要，可重复使用。
- 剂型：含液态植物提取物的胶囊，每粒净含量 830 mg。
- 每盒数量：120 粒。
每日 6 粒可提供：
* RSP——根据《TR TS 022/2011（欧亚经济联盟技术法规）》附录 2 规定的建议每日摄入水平。
AUP——根据《需接受卫生与流行病学监督（控制）的商品统一卫生、流行病学与卫生要求》附录 5 规定的适宜摄入量水平。
** 不超过欧亚经济联盟海关联盟上述文件附录 5 规定的最高允许摄入量。
禁忌：对成分个体不耐受者不建议使用。使用前建议咨询医生。
国家注册证书：№ RU.77.99.11.003.R.004962.12.21（2021-12-27）— 打开文件
AUP——根据《需接受卫生与流行病学监督（控制）的商品统一卫生、流行病学与卫生要求》附录 5 规定的适宜摄入量水平。
** 不超过欧亚经济联盟海关联盟上述文件附录 5 规定的最高允许摄入量。
禁忌：对成分个体不耐受者不建议使用。使用前建议咨询医生。
国家注册证书：№ RU.77.99.11.003.R.004962.12.21（2021-12-27）— 打开文件
Uña de gato / Cat's Claw（猫爪藤，Uncaria tomentosa）
Chuchuhuasi（丘丘瓦西，Maytenus macrocarpa）
Lapacho / Pau d’arco（拉帕乔/帕乌达尔科，Tabebuia avellanedae）
Uña de gato（乌尼亚·德·加托，直译“猫爪”）为茜草科（Rubiaceae）木质藤本植物，生长于中美洲与南美洲的热带雨林。其名称源自茎上尖锐弯曲的刺，能够帮助其攀附树木，外形酷似猫爪。
在“猫爪藤”这一通用名称下，常指两种植物：Uncaria tomentosa 与 Uncaria guianensis。二者在医学应用中主要因其显著的抗炎与免疫刺激特性而被使用。我们合作的希皮博（Shipibo）部族印第安人认为 Uncaria tomentosa 更为有效，因此 IMMUNO PLANTA® 采用的正是这一种。
民族药理学报告显示，南美原住民部族长期将 Uña de gato 用于哮喘、各种急性与慢性炎症过程、关节炎、风湿、乳腺癌、过敏、泌尿生殖系统炎症等。
体外（in vitro）与体内（in vivo）研究证实，该植物具有极为广泛的生物学作用。Uña de gato 的活性成分可抑制炎症过程，激活并增强免疫力，抑制肿瘤细胞扩散，并对变形链球菌（Streptococcus mutans）与葡萄球菌属（Staphylococcus spp.）表现出抗菌活性。Uña de gato 提取物可单独使用，亦可用于综合疗法中，以预防感冒、感染性与炎症性疾病；同时还可作为肿瘤疾病治疗的辅助，用于化疗后机体恢复并促进再生过程。
在“猫爪藤”这一通用名称下，常指两种植物：Uncaria tomentosa 与 Uncaria guianensis。二者在医学应用中主要因其显著的抗炎与免疫刺激特性而被使用。我们合作的希皮博（Shipibo）部族印第安人认为 Uncaria tomentosa 更为有效，因此 IMMUNO PLANTA® 采用的正是这一种。
民族药理学报告显示，南美原住民部族长期将 Uña de gato 用于哮喘、各种急性与慢性炎症过程、关节炎、风湿、乳腺癌、过敏、泌尿生殖系统炎症等。
体外（in vitro）与体内（in vivo）研究证实，该植物具有极为广泛的生物学作用。Uña de gato 的活性成分可抑制炎症过程，激活并增强免疫力，抑制肿瘤细胞扩散，并对变形链球菌（Streptococcus mutans）与葡萄球菌属（Staphylococcus spp.）表现出抗菌活性。Uña de gato 提取物可单独使用，亦可用于综合疗法中，以预防感冒、感染性与炎症性疾病；同时还可作为肿瘤疾病治疗的辅助，用于化疗后机体恢复并促进再生过程。
该植物化学成分中最重要的一类活性物质是其多种生物碱（主要的含氮碱性化合物）。与其他植物（包括同属 Uncaria 的其他种）相比，Uña de gato 中生物碱含量异常丰富。研究最充分的包括：四环氧吲哚生物碱（如 corincoxine、isocorincoxine、rhynchophylline、isorhynchophylline），其作用于中枢神经系统；以及五环氧吲哚生物碱（包括 mitraphylline、isomitraphylline、pteropodine、isopteropodine、speciophylline、uncarine F），其作用于免疫系统。
关于 Uña de gato 提取物抗炎活性所对应的具体成分，目前仍存在争议：一些研究者将其归因于五环氧吲哚生物碱，另一些则认为与酚类化合物（如绿原酸与奎尼酸）有关。同时也观察到，相比完整提取物，使用分离得到的单一活性成分时，抗炎效应会减弱。很可能 Uña de gato 的生物活性来自其所含多种化学成分的协同作用。因此，更推荐摄入完整提取物，而非从中分离出的单一成分。
另一个重要因素是：活性成分的浓度与季节及地理位置有关，因此 Uña de gato 需要在合适的地点与时节采收。若在南美特定区域之外以药用目的进行种植，意义不大。
关于 Uña de gato 提取物抗炎活性所对应的具体成分，目前仍存在争议：一些研究者将其归因于五环氧吲哚生物碱，另一些则认为与酚类化合物（如绿原酸与奎尼酸）有关。同时也观察到，相比完整提取物，使用分离得到的单一活性成分时，抗炎效应会减弱。很可能 Uña de gato 的生物活性来自其所含多种化学成分的协同作用。因此，更推荐摄入完整提取物，而非从中分离出的单一成分。
另一个重要因素是：活性成分的浓度与季节及地理位置有关，因此 Uña de gato 需要在合适的地点与时节采收。若在南美特定区域之外以药用目的进行种植，意义不大。
Chuchuhuasi（丘丘瓦西；亦写作 Chuchuwasha、Chuchuasi 等），学名 Maytenus macrocarpa，隶属卫矛科（Celastraceae）。Maytenus macrocarpa 为大型常绿乔木，高可达 30 米，树皮呈红棕色，枝条轮生。主要分布于秘鲁、玻利维亚、巴西、哥伦比亚与厄瓜多尔的低地热带雨林。
Chuchuhuasi 的树皮在玻利维亚、哥伦比亚、厄瓜多尔与秘鲁的部族医学中已使用了数百年。其秘鲁语名称意为“颤抖的背”，与其长期用于关节炎、风湿与背痛有关。Chuchuhuasi 还用于哮喘、感冒、咳嗽、支气管炎、流感等；作为退热、镇痛；用于疟疾；也被用作性欲下降时的兴奋剂，以及一般性的强身补益。比如，亚马逊当地居民常将 Chuchuhuasi 树皮浸泡于当地甘蔗朗姆酒中，作为“植物兴奋剂”（该饮品常被称为“跑步果汁”），以缓解肌肉疼痛并在长距离穿越雨林时提高耐力。
Maytenus macrocarpa 含有：ebinifoline 类生物碱、倍半萜类、黄酮类、甾醇、canophyllol、儿茶素类鞣质、达玛烷型三萜、dulcitol、friedelane 型三萜、酚类、macrocarpin 类三萜、maytansine、mebeverine、maytenin、pristimerin、原花青素以及 tingenone（及其衍生物）等。
Maytenus macrocarpa 含有：ebinifoline 类生物碱、倍半萜类、黄酮类、甾醇、canophyllol、儿茶素类鞣质、达玛烷型三萜、dulcitol、friedelane 型三萜、酚类、macrocarpin 类三萜、maytansine、mebeverine、maytenin、pristimerin、原花青素以及 tingenone（及其衍生物）等。
Lapacho（拉帕乔），亦称“蚂蚁树”，或 Pau d’arco（帕乌达尔科），是一种高大且花色绚丽的树木，生长于亚马逊雨林及南美塞拉多（Cerrado）等热带地区。
它是南美洲木质最坚硬的两种树之一：印第安人用其制作独木舟、船桨、弓以及农业工具。然而其最珍贵之处在于药用价值。药用部位为树皮。由于树皮与木质结合紧密，通常在树液流动期采收，此时树皮中的有效成分最为丰富。
在这棵树木享誉世界之前，南美印第安部族就已长期饮用其树皮煎剂，用于退热、感冒、各种肺部疾病、痢疾及其他胃肠道疾病、泌尿道感染、关节炎，并作为免疫调节手段。外用方面，树皮还用于溃疡、烧伤以及皮肤真菌感染。
目前，Lapacho 与 Uña de gato 一样，已被广泛用于综合性的免疫支持与抗炎方案。其树皮提取物用于胃肠道疾病、前列腺炎、泌尿道感染（膀胱炎、尿道炎、肾盂肾炎）、疟疾，以及感冒、流感等病毒性呼吸道感染和支气管-肺部疾病；也用于多种真菌/酵母感染，并在部分肿瘤疾病的治疗中得到应用。
它是南美洲木质最坚硬的两种树之一：印第安人用其制作独木舟、船桨、弓以及农业工具。然而其最珍贵之处在于药用价值。药用部位为树皮。由于树皮与木质结合紧密，通常在树液流动期采收，此时树皮中的有效成分最为丰富。
在这棵树木享誉世界之前，南美印第安部族就已长期饮用其树皮煎剂，用于退热、感冒、各种肺部疾病、痢疾及其他胃肠道疾病、泌尿道感染、关节炎，并作为免疫调节手段。外用方面，树皮还用于溃疡、烧伤以及皮肤真菌感染。
目前，Lapacho 与 Uña de gato 一样，已被广泛用于综合性的免疫支持与抗炎方案。其树皮提取物用于胃肠道疾病、前列腺炎、泌尿道感染（膀胱炎、尿道炎、肾盂肾炎）、疟疾，以及感冒、流感等病毒性呼吸道感染和支气管-肺部疾病；也用于多种真菌/酵母感染，并在部分肿瘤疾病的治疗中得到应用。
Lapacho 的益处源于其复杂的化学成分。主要活性成分之一为从树皮中提取的萘醌类，其中包括 lapachol 及其衍生物 α‑lapachone、β‑lapachone，以及近年发现的名为“xyloidone”的醌类化合物。另有 lapachenol、槲皮素（quercetin），以及邻/对‑羟基苯甲酸等成分。
研究发现：lapachol 具有抗微生物与抗病毒作用；β‑lapachone 表现出抗病毒活性；α‑lapachone 对寄生虫具有活性；xyloidone 对多种细菌与真菌有效。
现代科学研究还证实了 lapachol 及其衍生物对肿瘤细胞的影响（包括胰腺癌、肺癌、乳腺癌、前列腺癌等）。同时，有研究将从 Lapacho 树皮中分离得到的单体萘醌类视为潜在的肿瘤预防候选物，并可用于改善肿瘤患者的临床状态。
Lapacho 的另一成分——黄酮类槲皮素（quercetin）——对某些寄生虫具有细胞毒性。xyloidone 对广谱微生物有效，包括金黄色葡萄球菌（Staphylococcus aureus）以及布鲁氏菌属（Brucella spp.）。该成分还可抑制结核、痢疾与炭疽的病原体。lapachol、α‑lapachone、β‑lapachone 与 xyloidone 对大肠杆菌（E. coli，感染性膀胱炎与前列腺炎的主要病原）表现出的活性，也从侧面印证了 Lapacho 在传统上用于治疗与预防具有真菌或细菌性质的泌尿生殖系统疾病。
研究发现：lapachol 具有抗微生物与抗病毒作用；β‑lapachone 表现出抗病毒活性；α‑lapachone 对寄生虫具有活性；xyloidone 对多种细菌与真菌有效。
现代科学研究还证实了 lapachol 及其衍生物对肿瘤细胞的影响（包括胰腺癌、肺癌、乳腺癌、前列腺癌等）。同时，有研究将从 Lapacho 树皮中分离得到的单体萘醌类视为潜在的肿瘤预防候选物，并可用于改善肿瘤患者的临床状态。
Lapacho 的另一成分——黄酮类槲皮素（quercetin）——对某些寄生虫具有细胞毒性。xyloidone 对广谱微生物有效，包括金黄色葡萄球菌（Staphylococcus aureus）以及布鲁氏菌属（Brucella spp.）。该成分还可抑制结核、痢疾与炭疽的病原体。lapachol、α‑lapachone、β‑lapachone 与 xyloidone 对大肠杆菌（E. coli，感染性膀胱炎与前列腺炎的主要病原）表现出的活性，也从侧面印证了 Lapacho 在传统上用于治疗与预防具有真菌或细菌性质的泌尿生殖系统疾病。
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macrocarpa and Evaluation of Their Anti-HIV Activity // Natural Product Communications 2006. Vol. 1. No. 12
.1073 - 1078
60. Rivaldo Niero, Sérgio Faloni de Andrade and Valdir Cechinel Filho. A Review of the
Ethnopharmacology, Phytochemistry and Pharmacology of Plants of the Maytenus Genus// Current
Pharmaceutical Design, 2011, 17, 1-22
61. Salazar A., Loja B., Rabanal A., Mestanza S., Heringman K., Pinedo D., Alvarado Á.,
Castañeda B. Comparación de los usos del chuchuhuasi (Maytenus macrocarpa) entre indígenas Bora-Bora
de Loreto y chamanes de Lima (Perú) // Revista de Fitoterapia 2013; 13 (1): 61-69
62. Santoyo C. Z., Espinoza L. Z., Puente R. Z., Sánchez J. Z., Quispe N. Z., Medina C. P. and
Granara A. S. Antipsychotic and behavior effect of the ethanolic extract from the bark of Maytenus
macrocarpa (Ruiz &Pav.) Briq.in mice // Pharmacognosy Communications, 2015; 5, (4),: 244-249
63. Torpocco V., Chávez H., Estévez-Braun A., Ravelo Á. G. New Dammarane Triterpenes from
Maytenus macrocarpa. // Chem. Pharm. Bull. 2007; 55(5): 812—814
rheumatology: mechanisms of action, efficacy, and side effects. Semin Arthritis Rheum 2005;34(6):773-784.
5. Hardin, S. R. Cat's claw: an Amazonian vine decreases inflammation in
osteoarthritis. Complement Ther Clin Pract 2007;13(1):25-28.
6. Sandoval, M., Okuhama, N. N., Zhang, X. J., Condezo, L. A., Lao, J., Angeles', F. M.,
Musah, R. A., Bobrowski, P., and Miller, M. J. Anti-inflammatory and antioxidant activities of cat's claw
(Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid
content. Phytomedicine 2002;9(4):325-337
7. Senatore, A., Cataldo, A., Iaccarino, F. P., and Elberti, M. G. [Phytochemical and biological
study of Uncaria tomentosa]. Boll Soc Ital Biol Sper 1989;65(6):517-520
8. Gonçalves C, Dinis T, Batista MT. Antioxidant properties of proanthocyanidins of Uncaria
tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry. 2005 Jan;66(1):89-
98. doi: 10.1016/j.phytochem.2004.10.025. PMID: 15649515.
9. Miller, M. J., Mehta, K., Kunte, S., Raut, V., Gala, J., Dhumale, R., Shukla, A., Tupalli, H.,
Parikh, H., Bobrowski, P., and Chaudhary, J. Early relief of osteoarthritis symptoms with a natural mineral
supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. J Inflamm
(Lond) 10-21-2005;2:11.
10. Barnes J., Anderson L.A., Phillipson J.D. Herbal medcines. London - Pharmaceutical Press.
- third edition. 2007. 721 p.
11. Jalloh M.A., Gregory PJ, Hein D., R.Cochrane Z, Rodrigues A .Dietary supplement
interactions with antiretrovirals: a systematic review.// Int J STD AIDS 2017 Jan;28(1):4-15.
12. Akhtar N., Haqqi T.M. Current nutraceuticals in the management of osteoarthritis: a review //
Ther Adv Musculoskelet Dis. 2012 Jun;4(3):181-207
13. de Paula L.C., Fonseca F., Perazzo F. , Cruz FM, Cubero D, Trufeli DC, Martins SP, Santi
PX, da Silva EA, Del Giglio A. Uncaria tomentosa (cat's claw) improves quality of life in patients with
advanced solid tumors. /J Altern Complement Med. 2015 Jan;21(1):22-30
14. Santos A.Mdo C, Farias IL, Gutierres J, Dalmora SL, Flores N, Farias J, de Cruz I, Chiesa J,
Morscj VM, Chitolina Schetinger MR. Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical
Trial.// Evid Based Complement Alternat Med. 2012;2012:676984.
15. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced
toxicity of C-MED-100(TM), a novel aqueous extract from Uncaria tomentosa. //Journal of
Ethnopharmacology. 2000;69(2):115–126
16. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global
ethnopharmacological commodity? J Ethnopharmacol. 2009 Jan 12;121(1):1-13. doi:
10.1016/j.jep.2008.10.004. Epub 2008 Nov 1. PMID: 18992801.
17. Kuštrak, D. Taheebo-Lapacho-Tabebuia impetiginosa (syn. Tabebuia avellanedae)//
Farmaceutski Glasnik, Jan. 2001, 56 (6), p. 215-222
18. Bussmann R.W. (2018) Tabebuia avellanedae Lorentz ex Griseb.. In: Albuquerque U., Patil U.,
Máthé Á. (eds) Medicinal and Aromatic Plants of South America. Medicinal and Aromatic Plants of the World,
vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1552-0_40
19. Burnett AR, Thomson RH (1967b) Naturally occurring quinones. Part X. The quinonoid
constituents of Tabebuia avellanedae (Bignoniaceae). J Chem Soc (C): 2100-2104
20. Joseph E. Pizzorno, Michael T. Murray (2020). Textbook of Natural Medicine - E-Book, vol.5,
Elsevier Health Sciences. p. 868-872.
21. Hussain H, Green IR. Lapachol and lapachone analogs: a journey of two decades of patent
research(1997-2016). Expert Opin Ther Pat. 2017 Oct;27(10):1111-1121. doi:
10.1080/13543776.2017.1339792. Epub 2017 Jun 14. Erratum in: Expert Opin Ther Pat. 2017 Oct;27(10
):1173. PMID: 28586252
22. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 470-1
23. Bernardes A: A pocket book of Brazilian herbs: folklore, history, uses. Brazil, 1983, Shogun
Arte.
24. Lima, O.G.; D.Albuquerque, I. L., Gonçalves de Lima, C., Machado, M. P. Primeiras
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Castañeda B. Comparación de los usos del chuchuhuasi (Maytenus macrocarpa) entre indígenas Bora-Bora
de Loreto y chamanes de Lima (Perú) // Revista de Fitoterapia 2013; 13 (1): 61-69
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参考文献
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4. Setty, A. R. and Sigal, L. H. Herbal medications commonly used in the practice of
rheumatology: mechanisms of action, efficacy, and side effects. Semin Arthritis Rheum 2005;34(6):773-784.
5. Hardin, S. R. Cat's claw: an Amazonian vine decreases inflammation in
osteoarthritis. Complement Ther Clin Pract 2007;13(1):25-28.
6. Sandoval, M., Okuhama, N. N., Zhang, X. J., Condezo, L. A., Lao, J., Angeles', F. M.,
Musah, R. A., Bobrowski, P., and Miller, M. J. Anti-inflammatory and antioxidant activities of cat's claw
(Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid
content. Phytomedicine 2002;9(4):325-337
7. Senatore, A., Cataldo, A., Iaccarino, F. P., and Elberti, M. G. [Phytochemical and biological
study of Uncaria tomentosa]. Boll Soc Ital Biol Sper 1989;65(6):517-520
8. Gonçalves C, Dinis T, Batista MT. Antioxidant properties of proanthocyanidins of Uncaria
tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry. 2005 Jan;66(1):89-
98. doi: 10.1016/j.phytochem.2004.10.025. PMID: 15649515.
9. Miller, M. J., Mehta, K., Kunte, S., Raut, V., Gala, J., Dhumale, R., Shukla, A., Tupalli, H.,
Parikh, H., Bobrowski, P., and Chaudhary, J. Early relief of osteoarthritis symptoms with a natural mineral
supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. J Inflamm
(Lond) 10-21-2005;2:11.
10. Barnes J., Anderson L.A., Phillipson J.D. Herbal medcines. London - Pharmaceutical Press.
- third edition. 2007. 721 p.
11. Jalloh M.A., Gregory PJ, Hein D., R.Cochrane Z, Rodrigues A .Dietary supplement
interactions with antiretrovirals: a systematic review.// Int J STD AIDS 2017 Jan;28(1):4-15.
12. Akhtar N., Haqqi T.M. Current nutraceuticals in the management of osteoarthritis: a review //
Ther Adv Musculoskelet Dis. 2012 Jun;4(3):181-207
13. de Paula L.C., Fonseca F., Perazzo F. , Cruz FM, Cubero D, Trufeli DC, Martins SP, Santi
PX, da Silva EA, Del Giglio A. Uncaria tomentosa (cat's claw) improves quality of life in patients with
advanced solid tumors. /J Altern Complement Med. 2015 Jan;21(1):22-30
14. Santos A.Mdo C, Farias IL, Gutierres J, Dalmora SL, Flores N, Farias J, de Cruz I, Chiesa J,
Morscj VM, Chitolina Schetinger MR. Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical
Trial.// Evid Based Complement Alternat Med. 2012;2012:676984.
15. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced
toxicity of C-MED-100(TM), a novel aqueous extract from Uncaria tomentosa. //Journal of
Ethnopharmacology. 2000;69(2):115–126
16. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global
ethnopharmacological commodity? J Ethnopharmacol. 2009 Jan 12;121(1):1-13. doi:
10.1016/j.jep.2008.10.004. Epub 2008 Nov 1. PMID: 18992801.
17. Kuštrak, D. Taheebo-Lapacho-Tabebuia impetiginosa (syn. Tabebuia avellanedae)//
Farmaceutski Glasnik, Jan. 2001, 56 (6), p. 215-222
18. Bussmann R.W. (2018) Tabebuia avellanedae Lorentz ex Griseb.. In: Albuquerque U., Patil U.,
Máthé Á. (eds) Medicinal and Aromatic Plants of South America. Medicinal and Aromatic Plants of the World,
vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1552-0_40
19. Burnett AR, Thomson RH (1967b) Naturally occurring quinones. Part X. The quinonoid
constituents of Tabebuia avellanedae (Bignoniaceae). J Chem Soc (C): 2100-2104
20. Joseph E. Pizzorno, Michael T. Murray (2020). Textbook of Natural Medicine - E-Book, vol.5,
Elsevier Health Sciences. p. 868-872.
21. Hussain H, Green IR. Lapachol and lapachone analogs: a journey of two decades of patent
research(1997-2016). Expert Opin Ther Pat. 2017 Oct;27(10):1111-1121. doi:
10.1080/13543776.2017.1339792. Epub 2017 Jun 14. Erratum in: Expert Opin Ther Pat. 2017 Oct;27(10
):1173. PMID: 28586252
22. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 470-1
23. Bernardes A: A pocket book of Brazilian herbs: folklore, history, uses. Brazil, 1983, Shogun
Arte.
24. Lima, O.G.; D.Albuquerque, I. L., Gonçalves de Lima, C., Machado, M. P. Primeiras
Observações sobre a Ação Antimicrobiana do Lapachol.- Anaisda Sociedade de Biologia de Pernambuco
14, Nº 1/2, 129-135,1956.
25. Souza MA, Johann S, Lima LA, et al. The antimicrobial activity of lapachol and its
thiosemicarbazone and semicarbazone derivatives. Mem Inst Oswaldo Cruz. 2013;108(3):342-351.
doi:10.1590/S0074-02762013000300013
26. Machado TB, Pinto AV, Pinto MC, Leal IC, Silva MG, Amaral AC, Kuster RM, Netto-dosSantos
KR (2003) In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their
analogues, against methicillin-resistant Staphylococcus aureus. International Journal of Antimicrobial
Agents 21(3):279-284 doi: 10.1016/S0924-8579(02)00349-7
27. Yamashita M, Kaneko M, Tokuda H, Nishimura K, Kumeda Y, Iida A (2009) Synthesis and
evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae.
Bioorganic & Medicinal Chemistry 17(17):6286-6291 doi: 10.1016/j.bmc.2009.07.039.
28. Pereira EM, Machado Tde B, Leal IC, Jesus DM, Damaso CR, Pinto AV, Giambiagi-deMarval M,
Kuster RM, Santos KR (2006) Tabebuia avellanedae naphthoquinones: activity against methicillin-
resistant Staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis. Annals of Clinical
Microbiology and Antimicrobials 5:5 doi: 10.1186/1476-0711-5-5.
29. Guiraud P, Steiman R, Campos-Takaki GM, Seigle-Murandi F, Simeon de Buochberg M.
Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone. Planta Medica. 1994
Aug;60(4):373-374. DOI: 10.1055/s-2006-959504.
30. Twardowschy A, Freitas CS, Baggio CH, Mayer B, dos Santos AC, Pizzolatti MG, Zacarias AA,
dos Santos EP, Otuki MF, Marques MC (2008) Antiulcerogemc activity of bark extract of Tabebuia
avellanedae, Lorentz ex Griseb. Journal of Ethnopharmacology 118(3):455-459 doi:
10.1016/j.jep.2008.05.013.
31. Portillo A, Vila R, Freixa B, Adzet T, Canigueral S (2001) Antifungal activity of Paraguayan
plants used in traditional medicine. Journal of Ethnopharmacology 76(1):93-98.
32. Hofling JF, Anibal PC, Obando-Pereda GA, Peixoto IA, Furletti VF, Foglio MA, Goncalves RB
(2010) Antimicrobial potential of some plant extracts against Candida species. Brazilian Journal of
Biology 70(4):1065-1068 doi: 10.1590/S1519-69842010000500022.
33. Kreher B, Lotter H, Cordell GA, Wagner H. New Furanonaphthoquinones and other
Constituents of Tabebuia avellanedae and their Immunomodulating Activities in vitro. Planta Med. 1988
Dec;54(6):562-3. doi: 10.1055/s-2006-962561. PMID: 17265346
34. Kenneth Jones. Pau D'Arco: Immune Power from the Rain Forest. Inner Traditions / Bear & Co,
1995
35. Byeon SE, Chung JY, Lee YG, Kim BH, Kim KH, Cho JY (2008) In vitro and in vivo anti-
inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae. J
Ethnopharmacol 119(1):145–152
36. Ma S, Yada K, Lee H, Fukuda Y, Iida A, Suzuki K. Taheebo Polyphenols Attenuate Free Fatty
Acid-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of Cyclooxygenase-2.
Front Nutr. 2017 Dec 12;4:63. doi: 10.3389/fnut.2017.00063. Erratum in: Front Nutr. 2018 Jan 30;5:2. PMID:
29312947; PMCID: PMC5733013.
37. Lee MH, Choi HM, Hahm DH, et al. Analgesic and anti-inflammatory effects in animal models of
an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae. Molecular Medicine Reports. 2012
Oct;6(4):791-796. DOI: 10.3892/mmr.2012.989.
38. Rao, K.V.; Mcbride, T.J.; Oleson, J.J. Recognition and Evaluation of Lapachol as an Antitumor
Agent. Cancer Res. 1968, 28, 1952–1954
39. Hussain, H.; Green, I.R. Lapachol and lapachone analogs: A journey of two decades of patent
research (1997–2016). Expert Opin. Ther. Pat. 2017, 27, 1111–1121
40. Bang W, Jeon YJ, Cho JH, Lee RH, Park SM, Shin JC, Choi NJ, Choi YH, Cho JJ, Seo JM,
Lee SY, Shim JH, Chae JI. β-lapachone suppresses the proliferation of human malignant melanoma cells by
targeting specificity protein 1. Oncol Rep. 2016; 35(2):1109-16.
41. Chakrabarti G, Silvers MA, Ilcheva M, Liu Y, Moore ZR, Luo X, Gao J, Anderson G, Liu L,
Sarode V, Gerber DE, Burma S, DeBerardinis RJ, Gerson SL, Boothman DA. Tumor-selective use of DNA
base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.Sci
Rep. 2015 Nov 25; 5:17066.
42. Jeon YJ, Bang W, Shin JC, Park SM, Cho JJ, Choi YH, Seo KS, Choi NJ, Shim JH, Chae JI.
Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous
cell carcinoma. Int J Oncol. 2015;46(6):2606-12.
43. Hsiu-Ni Kung, Kuo-Shyan Lu and Yat-Pang Chau. The Chemotherapeutic Effects of Lapacho
Tree Extract: β-Lapachone. Kung et al., Chemotherapy 2014, 3:2 DOI: 10.4172/2167-7700.1000131.
44. Milan Malaník, Jakub Treml, Veronika Rjašková, Karolina Tížková, Petra Kaucká, Ladislav
Kokoška, Peter Kubatka and Karel Šmejkal, Adam Collins. Maytenus macrocarpa (Ruiz & Pav.) Briq.:
Phytochemistry and Pharmacological Activity. Received: 31 May 2019; Accepted: 18 June 2019; Published:
20 June 2019
45. Alberto Alcibiades Salazar Granara. Peruvian medicinal plants: Uses and biological effects
of Maytenus macrocarpa (Chuchuhuasi) and Jatropha curcas (Pinon blanco)/ 4th International Conference
and Exhibition on Pharmacognosy, Phytochemistry & Natural Products. August 29-31, 2016 Sao Paulo,
Brazil. Nat Prod Chem Res 2016, 4:5(Suppl)
46. Chavez H, Callo N, Estevez-Braun A, Ravelo AG, Gonzalez AG. Sesquiterpene polyol esters
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Maytenus macrocarpa.// J Nat Prod. 1998 Jan;61(1):82-5.
48. Chávez H, Rodríguez G, Estévez-Braun A, Ravelo AG, Estévez-Reyes R, González AG,
Fdez-Puente JL, García-Grávalos D. Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus
macrocarpa.// Bioorg Med Chem Lett. 2000 Apr 17;10(8): 759-762.
49. Celastraceae (Hippocrateoideae e Salacioideae) (Flora Neotropica Monograph 114) / Julio
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Peruvian medicinal plants used in Callería District.// J Ethnopharmacol. 2005; 99(2): 309-12
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activity of some medicinal barks used in Peruvian Amazon. // J. Ethnopharmacol. 2007; 111(2): 427-429
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Barrientos Herrera A.J., Urbano Farje O.J., Salazar Granara A.A. Evaluación de la actividad analgésica
central de las hojas de Maytenus macrocarpa (Ruiz & Pav.) Briq. (chuchuhuasi) // Revista Cubana de
Plantas Medicinales 2014;19(1):349-360
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55. Mejía Kember, Rengifo Eisa.Plantas Medicinales de Uso Popular en la Amazonía Peruana
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59. Piacente S., Campaner Dos Santos L., Mahmood N., Pizza C. Triterpenes from Maytenus
macrocarpa and Evaluation of Their Anti-HIV Activity // Natural Product Communications 2006. Vol. 1. No. 12
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60. Rivaldo Niero, Sérgio Faloni de Andrade and Valdir Cechinel Filho. A Review of the
Ethnopharmacology, Phytochemistry and Pharmacology of Plants of the Maytenus Genus// Current
Pharmaceutical Design, 2011, 17, 1-22
61. Salazar A., Loja B., Rabanal A., Mestanza S., Heringman K., Pinedo D., Alvarado Á.,
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Granara A. S. Antipsychotic and behavior effect of the ethanolic extract from the bark of Maytenus
macrocarpa (Ruiz &Pav.) Briq.in mice // Pharmacognosy Communications, 2015; 5, (4),: 244-249
63. Torpocco V., Chávez H., Estévez-Braun A., Ravelo Á. G. New Dammarane Triterpenes from
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inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae. J
Ethnopharmacol 119(1):145–152
36. Ma S, Yada K, Lee H, Fukuda Y, Iida A, Suzuki K. Taheebo Polyphenols Attenuate Free Fatty
Acid-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of Cyclooxygenase-2.
Front Nutr. 2017 Dec 12;4:63. doi: 10.3389/fnut.2017.00063. Erratum in: Front Nutr. 2018 Jan 30;5:2. PMID:
29312947; PMCID: PMC5733013.
37. Lee MH, Choi HM, Hahm DH, et al. Analgesic and anti-inflammatory effects in animal models of
an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae. Molecular Medicine Reports. 2012
Oct;6(4):791-796. DOI: 10.3892/mmr.2012.989.
38. Rao, K.V.; Mcbride, T.J.; Oleson, J.J. Recognition and Evaluation of Lapachol as an Antitumor
Agent. Cancer Res. 1968, 28, 1952–1954
39. Hussain, H.; Green, I.R. Lapachol and lapachone analogs: A journey of two decades of patent
research (1997–2016). Expert Opin. Ther. Pat. 2017, 27, 1111–1121
40. Bang W, Jeon YJ, Cho JH, Lee RH, Park SM, Shin JC, Choi NJ, Choi YH, Cho JJ, Seo JM,
Lee SY, Shim JH, Chae JI. β-lapachone suppresses the proliferation of human malignant melanoma cells by
targeting specificity protein 1. Oncol Rep. 2016; 35(2):1109-16.
41. Chakrabarti G, Silvers MA, Ilcheva M, Liu Y, Moore ZR, Luo X, Gao J, Anderson G, Liu L,
Sarode V, Gerber DE, Burma S, DeBerardinis RJ, Gerson SL, Boothman DA. Tumor-selective use of DNA
base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.Sci
Rep. 2015 Nov 25; 5:17066.
42. Jeon YJ, Bang W, Shin JC, Park SM, Cho JJ, Choi YH, Seo KS, Choi NJ, Shim JH, Chae JI.
Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous
cell carcinoma. Int J Oncol. 2015;46(6):2606-12.
43. Hsiu-Ni Kung, Kuo-Shyan Lu and Yat-Pang Chau. The Chemotherapeutic Effects of Lapacho
Tree Extract: β-Lapachone. Kung et al., Chemotherapy 2014, 3:2 DOI: 10.4172/2167-7700.1000131.
44. Milan Malaník, Jakub Treml, Veronika Rjašková, Karolina Tížková, Petra Kaucká, Ladislav
Kokoška, Peter Kubatka and Karel Šmejkal, Adam Collins. Maytenus macrocarpa (Ruiz & Pav.) Briq.:
Phytochemistry and Pharmacological Activity. Received: 31 May 2019; Accepted: 18 June 2019; Published:
20 June 2019
45. Alberto Alcibiades Salazar Granara. Peruvian medicinal plants: Uses and biological effects
of Maytenus macrocarpa (Chuchuhuasi) and Jatropha curcas (Pinon blanco)/ 4th International Conference
and Exhibition on Pharmacognosy, Phytochemistry & Natural Products. August 29-31, 2016 Sao Paulo,
Brazil. Nat Prod Chem Res 2016, 4:5(Suppl)
46. Chavez H, Callo N, Estevez-Braun A, Ravelo AG, Gonzalez AG. Sesquiterpene polyol esters
from the leaves of maytenus macrocarpa.// J Nat Prod. 1999 Nov;62(11):1576-7.
47. Chávez H., Estévez-Braun A., Ravelo AG., González AG. Friedelane triterpenoids from
Maytenus macrocarpa.// J Nat Prod. 1998 Jan;61(1):82-5.
48. Chávez H, Rodríguez G, Estévez-Braun A, Ravelo AG, Estévez-Reyes R, González AG,
Fdez-Puente JL, García-Grávalos D. Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus
macrocarpa.// Bioorg Med Chem Lett. 2000 Apr 17;10(8): 759-762.
49. Celastraceae (Hippocrateoideae e Salacioideae) (Flora Neotropica Monograph 114) / Julio
Antonio Lombardi. Publisher: The New York Botanical Garden Press, 2014 – 226 рр.
50. David Wolfe. Superfoods: The Food and Medicine of the Future. North Atlantic Books.2010.
352 p.
51. Kloucek P, Polesny Z, Svobodova B, Vlkova E., Kokoska L. Antibacterial screening of some
Peruvian medicinal plants used in Callería District.// J Ethnopharmacol. 2005; 99(2): 309-12
52. Kloucek P., Svobodova B., Polesny Z., Langrova I., Smrcek S., Kokoska L. Antimicrobial
activity of some medicinal barks used in Peruvian Amazon. // J. Ethnopharmacol. 2007; 111(2): 427-429
53. León Fernández A.M., Tupia Céspedes L.L., Turriate Montaldo Y., Maraví Rengifo J.E.,
Barrientos Herrera A.J., Urbano Farje O.J., Salazar Granara A.A. Evaluación de la actividad analgésica
central de las hojas de Maytenus macrocarpa (Ruiz & Pav.) Briq. (chuchuhuasi) // Revista Cubana de
Plantas Medicinales 2014;19(1):349-360
54. Leslie Taylor. The Healing Power of Rainforest Herbs: A Guide to Understanding and Using
Herbal Medicinals. ND – Square One Publishers, 2005. 528 р.
55. Mejía Kember, Rengifo Eisa.Plantas Medicinales de Uso Popular en la Amazonía Peruana
Lima, Agencia Española de Cooperación Internacional. Segunda edición corregida y aumentada: setiembre
2000. 286 p.
56. Meléndez-Espíritu S., Huaccho-Rojas J., Santos-Cajahuanca F., Abanto-Cabeza C.,
Jáuregui-Farfán J., Mendoza-Toribio J., Morales-Zenteno E., Salgado-Silva L., Sueyoshi-Hernández H.,
Robles-Ojeda M., Loja-Herrera B., Alvarado-Yarasca A., Salazar-Granara A. Interacciones farmacológicas
de las hojas de Maytenus macrocarpa o “chuchuhuasi” con fármacos inhibitorios y estimuladores de la
motilidad intestinal // Acta Med Per 2013; 30(4): 114-119
57. Nicholas Gill. Adventure Guide to Peru. Hunter Publishing, Inc, 2006 . 593 p.
58. Pérez-Victoria J,M., Tincusi B.M., Jiménez I.A., Bazzocchi I.L., Gupta M.P., Castanys S.,
Gamarro F., Ravelo A.G. New natural sesquiterpenes as modulators of daunomycin resistance in a
multidrug-resistant Leishmania tropica line.// J Med Chem. 1999 Oct 21;42(21):4388-93.
59. Piacente S., Campaner Dos Santos L., Mahmood N., Pizza C. Triterpenes from Maytenus
macrocarpa and Evaluation of Their Anti-HIV Activity // Natural Product Communications 2006. Vol. 1. No. 12
.1073 - 1078
60. Rivaldo Niero, Sérgio Faloni de Andrade and Valdir Cechinel Filho. A Review of the
Ethnopharmacology, Phytochemistry and Pharmacology of Plants of the Maytenus Genus// Current
Pharmaceutical Design, 2011, 17, 1-22
61. Salazar A., Loja B., Rabanal A., Mestanza S., Heringman K., Pinedo D., Alvarado Á.,
Castañeda B. Comparación de los usos del chuchuhuasi (Maytenus macrocarpa) entre indígenas Bora-Bora
de Loreto y chamanes de Lima (Perú) // Revista de Fitoterapia 2013; 13 (1): 61-69
62. Santoyo C. Z., Espinoza L. Z., Puente R. Z., Sánchez J. Z., Quispe N. Z., Medina C. P. and
Granara A. S. Antipsychotic and behavior effect of the ethanolic extract from the bark of Maytenus
macrocarpa (Ruiz &Pav.) Briq.in mice // Pharmacognosy Communications, 2015; 5, (4),: 244-249
63. Torpocco V., Chávez H., Estévez-Braun A., Ravelo Á. G. New Dammarane Triterpenes from
Maytenus macrocarpa. // Chem. Pharm. Bull. 2007; 55(5): 812—814
- 使用说明建议用法：男性在进餐开始时，每次 2 粒，每日 3 次。建议连续使用 20 天；如有需要，可重复使用。
- 剂型：含液态植物提取物的胶囊，每粒净含量 830 mg。
- 每盒数量：120 粒。
每日 6 粒可提供：
* RSP——根据《TR TS 022/2011（欧亚经济联盟技术法规）》附录 2 规定的建议每日摄入水平。
AUP——根据《需接受卫生与流行病学监督（控制）的商品统一卫生、流行病学与卫生要求》附录 5 规定的适宜摄入量水平。
** 不超过欧亚经济联盟海关联盟上述文件附录 5 规定的最高允许摄入量。
禁忌：对成分个体不耐受者不建议使用。使用前建议咨询医生。
国家注册证书：№ RU.77.99.11.003.R.004962.12.21（2021-12-27）— 打开文件
AUP——根据《需接受卫生与流行病学监督（控制）的商品统一卫生、流行病学与卫生要求》附录 5 规定的适宜摄入量水平。
** 不超过欧亚经济联盟海关联盟上述文件附录 5 规定的最高允许摄入量。
禁忌：对成分个体不耐受者不建议使用。使用前建议咨询医生。
国家注册证书：№ RU.77.99.11.003.R.004962.12.21（2021-12-27）— 打开文件
